Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.52 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.52 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.52 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | TYR | P14679 | 1/20 | 0.34 |
| ▸ | CA7 | P43166 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.34 |
| ▸ | GFPT1 | Q06210 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | TTR | P02766 | 1/20 | 0.32 |
| ▸ | APP | P05067 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6892352 | 1.00 | HCAR2 (0.52) | HCAR2NFE2L2KEAP1CA12CA1 | |
| SCHEMBL21127859 | 0.84 | HCAR2 (0.32) | HCAR2NFE2L2KEAP1ATMMEN1 | |
| SCHEMBL21126446 | 0.80 | ATM (0.48) | HCAR2ALDH1A1HSD17B10MAPTKDM4E | |
| SCHEMBL1871206 | 0.80 | HCAR2 (0.54) | HCAR2CA12CA1CA2CA7 | |
| SCHEMBL1406159 | 0.80 | HCAR2 (0.54) | HCAR2CA12CA1CA2CA7 | |
| SCHEMBL10985141 | 0.77 | HCAR2 (0.57) | HCAR2ALDH1A1MAPTKDM4EAPP | |
| SCHEMBL21126964 | 0.75 | ATM (0.53) | HCAR2ALDH1A1MAPTAPPATM | |
| SCHEMBL11144144 | 0.73 | TSHR (0.40) | HCAR2ALDH1A1TDP1TP53 | |
| SCHEMBL1013020 | 0.73 | — | — | |
| SCHEMBL9308560 | 0.73 | ALDH1A1 (0.32) | ALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103923765-A | Detergent Composition For Process Of Manufacturing Semiconductors And Displays | COWON INNOTECH INC | 2014-07-16 | — | — | CN | claimed |
| EP-2707367-B1 | METHODS FOR PREPARING NAPHTHYRIDINES | BIONOMICS LTD (AU) | 2019-10-09 | — | — | EP | disclosed |
| US-9133188-B2 | Methods for preparing naphthyridines | BIONOMICS LIMITED (AU) | 2015-09-15 | — | — | US | disclosed |
| CN-103923765-A | Detergent Composition For Process Of Manufacturing Semiconductors And Displays | COWON INNOTECH INC | 2014-07-16 | — | — | CN | disclosed |
| US-20140128600-A1 | METHODS FOR PREPARING NAPHTHYRIDINES | BIONOMICS LIMITED (AU) | 2014-05-08 | — | — | US | disclosed |
| EP-2707367-A1 | METHODS FOR PREPARING NAPHTHYRIDINES | Bionomics Limited (AU) | 2014-03-19 | — | — | EP | disclosed |
| WO-2012151640-A1 | METHODS FOR PREPARING NAPHTHYRIDINES | BIONOMICS LIMITED (AU) | 2012-11-15 | — | — | WO | disclosed |
| CN-101448840-B | Tetrahydropyridothienopyrimidine compounds and methods of use thereof | BAYER SCHERING PHARMA AG (DE) | 2011-12-14 | — | — | CN | disclosed |
| CN-101448840-A | Tetrahydropyridothienopyrimidine compounds and methods of use thereof | BAYER PHARMACEUTICALS CORP (DE) | 2009-06-03 | — | — | CN | disclosed |
| US-6777556-B2 | REACTING KETO-VINYL ETHER COMPOUND WITH DIALKYLAMINOACRYLATE COMPOUND TO OBTAIN DIALKYLAMINO-OXO-ESTER COMPOUND; REACTING WITH AMMONIA OR AMMONIUM COMPOUND TO FORM NICOTINIC ESTER COMPOUND, HYDROLYSIS | BAYER CHEMICALS AG (DE) | 2004-08-17 | — | — | US | disclosed |
| US-6706911-B1 | REACTING N-SUBSTITUTED 3-AMINOACRYLIC ESTERS WITH HALOALKYLCARBOXYLIC ANHYDRIDES IN PRESENCE OF BASE; PYRAZOLE-4-CARBOXYLIC ACID CHEMICAL INTERMEDIATES; HALOACYLATION | BAYER AKTIENGESELLSCHAFT (DE) | 2004-03-16 | — | — | US | disclosed |
| US-20030176468-A1 | Process for preparing 2-haloalkylnicotinic acids | LANXESS DEUTSCHLAND GMBH (DE) | 2003-09-18 | — | — | US | disclosed |
| EP-1340747-A1 | Process for the preparation of 2-halogene-alkyl nicotinic acid alkyl-esters | BAYER AG (DE) | 2003-09-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030176468-A1 | Process for preparing 2-haloalkylnicotinic acids | HDHD5, GNPAT, HACL2 | HCAR2 201/4885NFE2L2 1578/4885KEAP1 270/4885 |
| US-20140128600-A1 | METHODS FOR PREPARING NAPHTHYRIDINES | NQO1, CYP1A1, IPO4 | HCAR2 4162/4885NFE2L2 541/4885KEAP1 456/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.