Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 4/20 | 0.53 |
| ▸ | PRSS2 | P07478 | 4/20 | 0.53 |
| ▸ | PRSS3 | P35030 | 4/20 | 0.53 |
| ▸ | F10 | P00742 | 2/20 | 0.53 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.53 |
| ▸ | F2 | P00734 | 5/20 | 0.53 |
| ▸ | PLG | P00747 | 1/20 | 0.53 |
| ▸ | C1S | P09871 | 1/20 | 0.53 |
| ▸ | ST14 | Q9Y5Y6 | 4/20 | 0.49 |
| ▸ | CPN1 | P15169 | 1/20 | 0.49 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.49 |
| ▸ | TMPRSS6 | Q8IU80 | 2/20 | 0.46 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.45 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.45 |
| ▸ | NQO2 | P16083 | 1/20 | 0.45 |
| ▸ | WDR5 | P61964 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MASP2 | O00187 | 1/20 | 0.43 |
| ▸ | PLAU | P00749 | 1/20 | 0.43 |
| ▸ | THPO | P40225 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3444924 | 0.81 | EPHX1 (0.48) | LMNA | |
| SCHEMBL1064252 | 0.78 | TPH1 (0.66) | PRSS1PRSS2PRSS3F10LOXL2 | |
| SCHEMBL29123763 | 0.78 | HDAC6 (0.59) | — | |
| SCHEMBL7450129 | 0.78 | PRSS1 (0.50) | PRSS1PRSS2PRSS3F10LOXL2 | |
| SCHEMBL288202 | 0.78 | TPH1 (0.66) | PRSS1PRSS2PRSS3F10LOXL2 | |
| SCHEMBL1397441 | 0.78 | TPH1 (0.66) | PRSS1PRSS2PRSS3F10LOXL2 | |
| SCHEMBL7140360 | 0.78 | PRSS1 (0.50) | PRSS1PRSS2PRSS3F10LOXL2 | |
| SCHEMBL8952285 | 0.78 | PRSS1 (0.50) | PRSS1PRSS2PRSS3F10LOXL2 | |
| SCHEMBL20714851 | 0.78 | PRSS1 (0.50) | PRSS1PRSS2PRSS3F10LOXL2 | |
| SCHEMBL288201 | 0.78 | TPH1 (0.66) | PRSS1PRSS2PRSS3F10LOXL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6794365-B2 | INHIBITORS OF THE BLOOD CLOTTING ENZYME FACTOR XA; TREATING THROMBOEMBOLIC DISEASES; TRIFLUOROACETIC ACID SALT OF 2-(4-CARBAMIMIDOYL-BENZYL)-N-((1-CARBAMOYL-4-GUANIDINO-BUTYLCARBAMOYL) -CYCLOHEXYL-METHYL)-N',N'-DIMETHYL-MALONAMIDE | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2004-09-21 | — | — | US | disclosed |
| US-6395737-B1 | ANTICOAGULANTS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2002-05-28 | — | — | US | disclosed |