Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9729131 | 0.83 | HPGD (0.55) | HPGDALDH1A1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL9729327 | 0.80 | HPGD (0.51) | HPGDALDH1A1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL25374756 | 0.77 | HPGD (0.45) | HPGDALDH1A1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL24724282 | 0.76 | HPGD (0.50) | HPGDALDH1A1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL15671001 | 0.74 | ANPEP (0.45) | HPGDL3MBTL1SMN1; SMN2 | |
| SCHEMBL6325983 | 0.72 | HPGD (0.64) | HPGDALDH1A1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL3469149 | 0.72 | LMNA (0.36) | HPGDALDH1A1CYP3A4CYP2C19KDM4E | |
| SCHEMBL6895263 | 0.71 | KDM4E (0.43) | ALDH1A1CYP2D6KDM4ECYP1A2L3MBTL1 | |
| SCHEMBL6894924 | 0.71 | KDM4E (0.43) | ALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL9729453 | 0.71 | HPGD (0.56) | HPGDALDH1A1CYP3A4CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2004502669-A | — | — | 2004-01-29 | — | — | JP | claimed |
| EP-1353898-A2 | COMPOUNDS TO TREAT ALZHEIMER'S DISEASE | Elan Pharmaceuticals, Inc. (US) | 2003-10-22 | — | — | EP | claimed |
| WO-2002002512-A2 | COMPOUNDS TO TREAT ALZHEIMER'S DISEASE | ELAN PHARMACEUTICALS, INC. (US) | 2002-01-10 | — | — | WO | claimed |