Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | ANPEP | P15144 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | AOC3 | Q16853 | 6/20 | 0.41 |
| ▸ | APAF1 | O14727 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6895263 | 0.90 | KDM4E (0.43) | KDM4EADRA2AADRA2CLMNAHIF1A | |
| SCHEMBL6894568 | 0.84 | CYP3A4 (0.44) | KDM4EADRA2AADRA2CLMNAHIF1A | |
| SCHEMBL6887737 | 0.82 | ANPEP (0.37) | KDM4EADRA2AADRA2CLMNAHIF1A | |
| SCHEMBL6895745 | 0.82 | LMNA (0.47) | KDM4EADRA2AADRA2CLMNAHIF1A | |
| SCHEMBL29433956 | 0.81 | AOC3 (0.53) | KDM4EADRA2AADRA2CLMNAHIF1A | |
| SCHEMBL6889436 | 0.80 | SIGMAR1 (0.49) | ADRA2ALMNAHIF1AANPEPALDH1A1 | |
| SCHEMBL6895074 | 0.78 | HPGD (0.44) | KDM4EADRA2AADRA2CLMNAHIF1A | |
| SCHEMBL9286355 | 0.78 | AOC3 (0.42) | KDM4EADRA2AADRA2CLMNAHIF1A | |
| SCHEMBL6893793 | 0.78 | CYP3A4 (0.33) | — | |
| SCHEMBL6895959 | 0.77 | ADRA2C (0.47) | KDM4EADRA2AADRA2CLMNAHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2004502669-A | — | — | 2004-01-29 | — | — | JP | claimed |
| EP-1353898-A2 | COMPOUNDS TO TREAT ALZHEIMER'S DISEASE | Elan Pharmaceuticals, Inc. (US) | 2003-10-22 | — | — | EP | claimed |
| WO-2002002512-A2 | COMPOUNDS TO TREAT ALZHEIMER'S DISEASE | ELAN PHARMACEUTICALS, INC. (US) | 2002-01-10 | — | — | WO | claimed |