SCHEMBL6893492

SCHEMBL6893492

NCCNC(=O)C(Cc1ccc(N)cc1)C(=O)NCCN

nearest known ligand 0.48

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
MMP8 P22894 2/20 0.46
SOAT1 P35610 1/20 0.42
MME P08473 1/20 0.42
TRPV1 Q8NER1 1/20 0.41
HDAC1 Q13547 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9015449 0.91 CHRND (0.48) MMP8
SCHEMBL8829950 0.80 LMNA (0.49)
SCHEMBL14269025 0.74 LDHA (0.57) SOAT1
SCHEMBL6896196 0.72 EPHX1 (0.46) SOAT1
SCHEMBL21919162 0.72 SLC7A5 (0.57)
SCHEMBL3992599 0.70 PTPRB (0.58) SOAT1
SCHEMBL12613755 0.70 CHRM1 (0.65) TRPV1
SCHEMBL28862293 0.69 PPARG (0.50) SOAT1
SCHEMBL11619588 0.69 TSHR (0.70) HDAC1
Hydrochloric Acid SCHEMBL3526195 0.69 PTPRB (0.56) SOAT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0699079-B1 BIOACTIVE AND/OR TARGETED DENDRIMER CONJUGATES COMPRISING GENETIC MATERIALS DOW CHEMICAL CO (US) 2004-09-29 EP disclosed
US-6312679-B1 Dense star polymer conjugates as dyes THE DOW CHEMICAL COMPANY 2001-11-06 US disclosed
US-6177414-B1 POLYMAMINOAMIDE DENDRIMER STAR POLYMER CARRYING SALICYLIC ACID MOIETIES; DRUG DELIVERY THE DOW CHEMICAL COMPANY 2001-01-23 US disclosed
US-5714166-A Bioactive and/or targeted dendrimer conjugates THE DOW CHEMICAL COMPANY (US) 1998-02-03 US disclosed
EP-0271180-B2 Starburst conjugates DOW CHEMICAL CO (US) 1997-06-18 EP disclosed
US-5527524-A AGRICULTURAL, PHARMACEUTICAL, DRUG DELIVERY THE DOW CHEMICAL COMPANY (US) 1996-06-18 US disclosed
EP-0699079-A1 BIOACTIVE AND/OR TARGETED DENDRIMER CONJUGATES THE DOW CHEMICAL COMPANY (US) 1996-03-06 EP disclosed
US-5489425-A RHODIUM COMPLEXES ATTACHED TO ANTIBODY OR FAB FRAGMENTS FOR THERAPY OR MEDICAL DIAGNOSIS; ANTICARCINOGENIC AND -TUMOR AGENTS; RADIOLOGY; IMMUNOLOGY THE DOW CHEMICAL COMPANY (US) 1996-02-06 US disclosed
WO-1995024221-A1 BIOACTIVE AND/OR TARGETED DENDRIMER CONJUGATES THE DOW CHEMICAL COMPANY (US) 1995-09-14 WO disclosed
US-5338532-A Star polymer as carrier for drugs, agricultural compounds THE DOW CHEMICAL COMPANY (US) 1994-08-16 US disclosed
US-5284644-A Anticancer agent; therapy and diagnosis DOW CHEMICAL COMPANY, THE 1994-02-08 US disclosed
EP-0271180-A1 Starburst conjugates THE DOW CHEMICAL COMPANY (US) 1988-06-15 EP disclosed
WO-1988001178-A1 STARBURST CONJUGATES THE DOW CHEMICAL COMPANY (US) 1988-02-25 WO disclosed
WO-1988001179-A1 STARBURST CONJUGATES THE DOW CHEMICAL COMPANY (US) 1988-02-25 WO disclosed
WO-1988001180-A1 STARBURST CONJUGATES THE DOW CHEMICAL COMPANY (US) 1988-02-25 WO disclosed