Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 6/20 | 0.39 |
| ▸ | CES2 | O00748 | 1/20 | 0.36 |
| ▸ | CES1 | P23141 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | CA4 | P22748 | 1/20 | 0.33 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Potassium Ion SCHEMBL38661171 | 1.00 | EPHX1 (0.39) | EPHX1CES2CES1MEN1KMT2A | |
| Potassium Ion SCHEMBL18342686 | 1.00 | EPHX1 (0.39) | EPHX1CES2CES1MEN1KMT2A | |
| Potassium Ion SCHEMBL29116637 | 0.97 | CA4 (0.39) | EPHX1CES2CES1MEN1KMT2A | |
| SCHEMBL5248085 | 0.94 | EPHX1 (0.39) | EPHX1CES2CES1MEN1KMT2A | |
| SCHEMBL1893677 | 0.94 | EPHX1 (0.39) | EPHX1CES2CES1MEN1KMT2A | |
| SCHEMBL504432 | 0.94 | EPHX1 (0.39) | EPHX1CES2CES1MEN1KMT2A | |
| Lithium Ion SCHEMBL1588970 | 0.94 | EPHX1 (0.39) | EPHX1CES2CES1MEN1KMT2A | |
| SCHEMBL21808834 | 0.94 | EPHX1 (0.39) | EPHX1CES2CES1MEN1KMT2A | |
| SCHEMBL21808833 | 0.94 | EPHX1 (0.39) | EPHX1CES2CES1MEN1KMT2A | |
| Zinc Ion SCHEMBL2411292 | 0.94 | EPHX1 (0.39) | EPHX1CES2CES1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6780403-B1 | DEODORANT INCLUDING ORGANIC DIBASIC ACID AND/OR ALKALI METAL, AMMONIUM, ZINC OR ALUMINUM SALT; ACID HAS DIFFERENCE BETWEEN FIRST AND SECOND ACID DISSOCIATION INDICES OF 1.7 OR MORE AT 25 DEGREES C. AND SECOND DISSOCIATION INDEX IS FROM 6 TO 8 | KAO CORPORATION (JP) | 2004-08-24 | — | — | US | disclosed |
| EP-1197204-A1 | DEODORANTS | Kao Corporation (JP) | 2002-04-17 | — | — | EP | disclosed |