Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | CASR | P41180 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | TDO2 | P48775 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 2/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6887215 | 0.90 | MAOB (0.41) | IDO1MAOBMAOASCN9A | |
| SCHEMBL6892044 | 0.89 | LMNA (0.38) | ALDH1A1LMNAMAPK1HTTNPSR1 | |
| SCHEMBL6895046 | 0.89 | IDO1 (0.33) | IDO1MAOBMAOASCN9A | |
| SCHEMBL5578711 | 0.87 | BACE1 (0.35) | ALDH1A1MEN1KMT2AKDM4EMAOB | |
| SCHEMBL6893114 | 0.87 | SIGMAR1 (0.42) | SIGMAR1POLBALDH1A1ADRB2KDM4E | |
| SCHEMBL6889713 | 0.86 | MEN1 (0.40) | SIGMAR1CYP1A2CYP2D6CYP2C19IDO1 | |
| SCHEMBL6895745 | 0.86 | LMNA (0.47) | SIGMAR1POLBALDH1A1LMNAMAPK1 | |
| SCHEMBL6888146 | 0.85 | GBA1 (0.34) | ALDH1A1LMNAMAPK1HTTKMT2A | |
| SCHEMBL6894740 | 0.84 | TAAR1 (0.46) | ALDH1A1LMNAADRB2CASRIDO1 | |
| SCHEMBL6895816 | 0.84 | HTR2A (0.48) | SIGMAR1LMNACASRCYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2004502669-A | — | — | 2004-01-29 | — | — | JP | claimed |
| EP-1353898-A2 | COMPOUNDS TO TREAT ALZHEIMER'S DISEASE | Elan Pharmaceuticals, Inc. (US) | 2003-10-22 | — | — | EP | claimed |
| WO-2002002512-A2 | COMPOUNDS TO TREAT ALZHEIMER'S DISEASE | ELAN PHARMACEUTICALS, INC. (US) | 2002-01-10 | — | — | WO | claimed |