Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 6/20 | 0.49 |
| ▸ | GRIN2B | Q13224 | 6/20 | 0.49 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | GALR3 | O60755 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | HSD17B13 | Q7Z5P4 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | FEN1 | P39748 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6773039 | 0.92 | NOX4 (0.43) | GRIN1GRIN2BNOX4ALDH1A1GALR3 | |
| SCHEMBL6895819 | 0.89 | GRIN1 (0.50) | GRIN1GRIN2BNOX4ALDH1A1GALR3 | |
| SCHEMBL6777226 | 0.88 | ADRA1D (0.43) | ALDH1A1ADRA1DLMNAKDM4EMEN1 | |
| SCHEMBL7968669 | 0.86 | GRIN1 (0.44) | GRIN1GRIN2B | |
| SCHEMBL6770301 | 0.86 | PLA2G2A (0.41) | ALDH1A1RAB9ASMN1; SMN2LMNAMAPT | |
| SCHEMBL6782583 | 0.86 | ALDH1A1 (0.41) | ALDH1A1RAB9ATSHRLMNAMAPT | |
| SCHEMBL6771780 | 0.86 | IKBKB (0.37) | GRIN1GRIN2BADRA1DFEN1 | |
| SCHEMBL6688460 | 0.85 | ALDH1A1 (0.46) | NOX4ALDH1A1GALR3RAB9ASMN1; SMN2 | |
| SCHEMBL6775902 | 0.85 | PLA2G2A (0.42) | — | |
| SCHEMBL6776015 | 0.85 | MCL1 (0.44) | ALDH1A1SMN1; SMN2MAPTKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6713645-B1 | INHIBITING SPLA2 MEDIATED RELEASE OF FATTY ACIDS FOR TREATMENT OF CONDITIONS SUCH AS SEPTIC SHOCK | ELI LILLY AND COMPANY | 2004-03-30 | — | — | US | disclosed |
| US-6177440-B1 | THERAPY FOR SEPSIS SHOCK; PHOSPHOLIPASE INHBITOR | ELI LILLY AND COMPANY | 2001-01-23 | — | — | US | disclosed |
| EP-0952149-A2 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitiors | ELI LILLY AND COMPANY (US) | 1999-10-27 | — | — | EP | disclosed |