Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 5/20 | 0.34 |
| ▸ | CNR2 | P34972 | 5/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.31 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | CASR | P41180 | 1/20 | 0.31 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6898335 | 0.86 | CNR1 (0.36) | CNR1CNR2SIGMAR1KDM4EALDH1A1 | |
| SCHEMBL6898252 | 0.82 | HSD11B1 (0.36) | SIGMAR1KDM4EALDH1A1HSD11B1LMNA | |
| SCHEMBL6897959 | 0.81 | TP53 (0.36) | SIGMAR1KDM4EALDH1A1HSD11B1LMNA | |
| SCHEMBL6897826 | 0.81 | TP53 (0.36) | SIGMAR1KDM4EALDH1A1HSD11B1LMNA | |
| SCHEMBL6898851 | 0.81 | TP53 (0.36) | SIGMAR1KDM4EALDH1A1HSD11B1LMNA | |
| SCHEMBL7664089 | 0.80 | TP53 (0.35) | SIGMAR1KDM4EALDH1A1CHRM3TP53 | |
| SCHEMBL6895838 | 0.80 | SIGMAR1 (0.31) | SIGMAR1KDM4EALDH1A1HSD11B1LMNA | |
| SCHEMBL6897336 | 0.80 | TP53 (0.34) | SIGMAR1CHRM3HDAC3HDAC8TP53 | |
| SCHEMBL6891136 | 0.79 | CTSB (0.32) | SIGMAR1KDM4EALDH1A1LMNA | |
| SCHEMBL7510265 | 0.79 | SIGMAR1 (0.42) | CNR1SIGMAR1ALDH1A1HSD11B1HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6730784-B2 | AS THERAPEUTIC AGENTS FOR AUTOIMMUNE DISEASES SUCH AS RHEUMATOID ARTHRITIS | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2004-05-04 | — | — | US | disclosed |
| US-20020198376-A1 | Novel urea derivatives | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2002-12-26 | — | — | US | disclosed |
| CN-1299344-A | Novel urea derivatives | SANTEN PHARCEUMATICAL CO LTD (JP) | 2001-06-13 | — | — | CN | disclosed |
| EP-1072591-A1 | NOVEL UREA DERIVATIVES | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2001-01-31 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020198376-A1 | Novel urea derivatives | TNF, CTH, CFH | CNR1 207/4885CNR2 383/4885SIGMAR1 26/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.