Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.40 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.40 |
| ▸ | KIF11 | P52732 | 3/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | LDHA | P00338 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 2/20 | 0.38 |
| ▸ | HSD17B13 | Q7Z5P4 | 2/20 | 0.38 |
| ▸ | PPARG | P37231 | 2/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6776501 | 0.89 | EPHX2 (0.40) | EPHX2NR1H2NR1H3KIF11RORC | |
| SCHEMBL6889740 | 0.88 | SLC6A4 (0.41) | HSP90AA1HSP90B1P2RX7ABCB1SLC6A4 | |
| SCHEMBL6887896 | 0.88 | MAPT (0.44) | ABCB1SLC6A4SLC6A3DRD2TBXA2R | |
| SCHEMBL6897905 | 0.87 | DRD2 (0.43) | HSP90AA1HSP90B1SLC6A4SLC6A3DRD2 | |
| SCHEMBL6896346 | 0.86 | SLC6A3 (0.41) | HSP90AA1HSP90B1P2RX7ABCB1SLC6A4 | |
| SCHEMBL6896006 | 0.86 | RORC (0.42) | HSP90AA1HSP90B1P2RX7EPHX2KIF11 | |
| SCHEMBL6690879 | 0.86 | DRD2 (0.47) | P2RX7SLC6A4SLC6A3DRD2TBXA2R | |
| SCHEMBL6694438 | 0.86 | P2RX7 (0.44) | HSP90AA1HSP90B1P2RX7EPHX2KIF11 | |
| SCHEMBL6894724 | 0.85 | SLC6A3 (0.48) | SLC6A4SLC6A3DRD2TBXA2RPPARG | |
| SCHEMBL6889876 | 0.85 | MAPK8 (0.44) | SLC6A4SLC6A3DRD2TBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6713645-B1 | INHIBITING SPLA2 MEDIATED RELEASE OF FATTY ACIDS FOR TREATMENT OF CONDITIONS SUCH AS SEPTIC SHOCK | ELI LILLY AND COMPANY | 2004-03-30 | — | — | US | disclosed |
| US-6177440-B1 | THERAPY FOR SEPSIS SHOCK; PHOSPHOLIPASE INHBITOR | ELI LILLY AND COMPANY | 2001-01-23 | — | — | US | disclosed |
| EP-0952149-A2 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitiors | ELI LILLY AND COMPANY (US) | 1999-10-27 | — | — | EP | disclosed |