Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.36 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.36 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.36 |
| ▸ | GRN | P28799 | 1/20 | 0.35 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.33 |
| ▸ | PTGES | O14684 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6897332 | 1.00 | LTA4H (0.38) | LTA4HSLC1A3SLC1A2SLC1A1GRN | |
| SCHEMBL27335896 | 0.91 | LTA4H (0.36) | LTA4HGRNSORT1 | |
| SCHEMBL6899551 | 0.91 | ANPEP (0.33) | GRNSORT1 | |
| SCHEMBL6899558 | 0.91 | ANPEP (0.33) | GRNSORT1 | |
| SCHEMBL27523629 | 0.75 | THRB (0.42) | — | |
| SCHEMBL7435877 | 0.72 | CPB2 (0.44) | LTA4H | |
| SCHEMBL1733951 | 0.72 | SLC1A3 (0.44) | LTA4HSLC1A3SLC1A2SLC1A1GRN | |
| SCHEMBL1101396 | 0.71 | EPHX1 (0.39) | — | |
| SCHEMBL27337149 | 0.71 | SMN1; SMN2 (0.46) | — | |
| SCHEMBL14947101 | 0.71 | LTA4H (0.46) | LTA4HSLC1A3SLC1A2SLC1A1CTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0629627-B1 | Bicyclic carboxylic acids and their derivatives as nep and aca inhibitors | BRISTOL MYERS SQUIBB CO (US) | 2004-05-06 | — | — | EP | disclosed |
| CN-1046525-C | Compounds containing a fused bicyclic ring and processes therefor | BRISTOL MYERS SQUIBB CO (US) | 1999-11-17 | — | — | CN | disclosed |
| US-5756832-A | REACTING AN ALDHYDE WITH AN ORTHOFORMATE IN THE PRESENCE OF AN ACID CATALYST AND AN ALCOHOL | BRISTOL-MYERS SQUIBB CO. (US) | 1998-05-26 | — | — | US | disclosed |
| US-5672599-A | DUAL ACTION ANGIOTENSIN CONVERTING ENZYME INHIBITORS AND NEUTRAL ENDOPEPTIDASE INHIBITORS; TREATMENT OF CARDIOVASCULAR DISORDERS | BRISTOL-MYERS SQUIBB CO. (US) | 1997-09-30 | — | — | US | disclosed |
| US-5670699-A | Process for preparing amino acid esters useful as intermediates for compounds containing a fused bicyclic ring | BRISTOL-MYERS SQUIBB CO. (US) | 1997-09-23 | — | — | US | disclosed |
| US-5627278-A | MULTISTAGE REACTION FORMED BY AMIDATION, COUPLING AND REDUCTION | BRISTOL-MYERS SQUIBB CO. (US) | 1997-05-06 | — | — | US | disclosed |
| US-5616775-A | ESTERIFYING A N-PROTECTED METHIONINE; OXIDIZING; REACTING WITH AN ACID ANHYDRIDE THEN AN ALKALI METAL HYDROXIDE | BRISTOL-MYERS SQUIBB CO. (US) | 1997-04-01 | — | — | US | disclosed |
| US-5508272-A | SELECTIVE ACE INHIBITORS, HYPOTENSIVE AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-04-16 | — | — | US | disclosed |
| EP-0629627-A2 | Bicyclic carboxylic acids and their derivatives as nep and aca inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 1994-12-21 | — | — | EP | disclosed |