Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | DHFR | P00374 | 1/20 | 0.36 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.35 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6895496 | 0.86 | DHFR (0.35) | KDM4ESMN1; SMN2ALDH1A1TSHRHSD17B10 | |
| Hydrochloric Acid SCHEMBL6903334 | 0.85 | TGFBR1 (0.38) | KDM4ESMN1; SMN2LMNAMAPTPKM | |
| SCHEMBL6902284 | 0.84 | KDM4E (0.43) | KDM4ESMN1; SMN2LMNAMAPTPKM | |
| Hydrochloric Acid SCHEMBL6903579 | 0.83 | SYK (0.40) | KDM4ESMN1; SMN2LMNAMAPTPKM | |
| Hydrochloric Acid SCHEMBL6903521 | 0.83 | TGFBR1 (0.39) | MAPTTP53HTTTDP1 | |
| Hydrochloric Acid SCHEMBL6901138 | 0.82 | KDM4E (0.43) | KDM4ESMN1; SMN2LMNAMAPTTP53 | |
| Hydrochloric Acid SCHEMBL6902696 | 0.81 | PDK2 (0.30) | — | |
| Hydrochloric Acid SCHEMBL6904281 | 0.81 | NPC1 (0.34) | KDM4ESMN1; SMN2LMNAMAPTTSHR | |
| Hydrochloric Acid SCHEMBL6904878 | 0.81 | TRPV1 (0.39) | KDM4EMAPTALDH1A1NPSR1HSD17B10 | |
| Hydrochloric Acid SCHEMBL6898085 | 0.79 | BACE1 (0.35) | KDM4EDHFRADORA2AADORA1GSTP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1033371-B1 | Transition metal compound, catalyst system, process for the preparation thereof and its use for the polymerization of olefins | BASELL POLYOLEFINE GMBH (DE) | 2004-01-28 | — | — | EP | claimed |
| US-6458982-B1 | CATALYST SYSTEM COMPRISING AT LEAST ONE METALLOCENE AND AT LEAST ONE COCATALYST. ON SUPPORT. | TARGOR GMBH (DE) | 2002-10-01 | — | — | US | disclosed |