Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | TP53 | P04637 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 2/20 | 0.39 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | CCR1 | P32246 | 2/20 | 0.35 |
| ▸ | CCR5 | P51681 | 2/20 | 0.35 |
| ▸ | CCR8 | P51685 | 2/20 | 0.35 |
| ▸ | ALPL | P05186 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6905141 | 0.85 | CYP11B1 (0.36) | KDM4ESMN1; SMN2ALDH1A1MAPTHPGD | |
| Hydrochloric Acid SCHEMBL6903334 | 0.83 | TGFBR1 (0.38) | KDM4ESMN1; SMN2ALDH1A1MAPTHPGD | |
| SCHEMBL6901048 | 0.82 | KDM4E (0.46) | KDM4ESMN1; SMN2ALDH1A1MAPTHPGD | |
| Hydrochloric Acid SCHEMBL6897596 | 0.82 | KDM4E (0.41) | KDM4ESMN1; SMN2ALDH1A1MAPTTP53 | |
| Hydrochloric Acid SCHEMBL6903579 | 0.79 | SYK (0.40) | KDM4ESMN1; SMN2ALDH1A1MAPTHPGD | |
| Hydrochloric Acid SCHEMBL6901127 | 0.77 | CA12 (0.35) | KDM4EALDH1A1HPGDHSD17B10HTR2C | |
| Hydrochloric Acid SCHEMBL6904281 | 0.77 | NPC1 (0.34) | KDM4ESMN1; SMN2MAPTHPGDNPC1 | |
| Hydrochloric Acid SCHEMBL6902696 | 0.77 | PDK2 (0.30) | PDK2 | |
| Hydrochloric Acid SCHEMBL7061934 | 0.77 | KDM4E (0.33) | KDM4ESMN1; SMN2ALDH1A1MAPTHPGD | |
| Hydrochloric Acid SCHEMBL6903521 | 0.76 | TGFBR1 (0.39) | MAPTTP53TGFBR1TDP1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1033371-B1 | Transition metal compound, catalyst system, process for the preparation thereof and its use for the polymerization of olefins | BASELL POLYOLEFINE GMBH (DE) | 2004-01-28 | — | — | EP | claimed |
| US-6458982-B1 | CATALYST SYSTEM COMPRISING AT LEAST ONE METALLOCENE AND AT LEAST ONE COCATALYST. ON SUPPORT. | TARGOR GMBH (DE) | 2002-10-01 | — | — | US | disclosed |