Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 4/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.35 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.35 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.35 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.35 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.35 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL790543 | 0.81 | SIGMAR1 (0.37) | HSD11B1HDAC4OPRM1SIGMAR1P2RX7 | |
| SCHEMBL24728921 | 0.76 | ALDH1A1 (0.42) | HSD11B1PDK2OPRK1 | |
| SCHEMBL23177230 | 0.75 | SLC6A2 (0.44) | HSD11B1PDK2SIGMAR1 | |
| SCHEMBL6933296 | 0.75 | SIGMAR1 (0.37) | HSD11B1HDAC4SIGMAR1P2RX7GRIN2B | |
| SCHEMBL6897911 | 0.74 | ALDH1A1 (0.35) | HSD11B1HDAC4OPRM1SIGMAR1P2RX7 | |
| SCHEMBL7081965 | 0.74 | HSD11B1 (0.34) | HSD11B1HDAC4OPRM1SIGMAR1P2RX7 | |
| Hydrochloric Acid SCHEMBL6930722 | 0.74 | SIGMAR1 (0.36) | HSD11B1HDAC4SIGMAR1P2RX7GRIN2B | |
| SCHEMBL23319128 | 0.73 | PDK2 (0.44) | HSD11B1PDK2P2RX7 | |
| SCHEMBL24604948 | 0.73 | PDK2 (0.40) | HSD11B1PDK2P2RX7 | |
| Hydrochloric Acid SCHEMBL6899621 | 0.73 | HSD11B1 (0.40) | HSD11B1SIGMAR1P2RX7GRIN2BGRIN2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1143964-B1 | 2-ADAMANTANEMETHANAMINE COMPOUNDS FOR TREATING ABNORMALITIES IN GLUTAMATERGIC TRANSMISSION | VERNALIS RES LTD (GB) | 2004-03-24 | — | — | EP | disclosed |
| EP-1051392-B1 | ADAMANTANECARBOXIMIDAMIDE DERIVATIVES AND THEIR USE AS NMDA ANTAGONISTS | VERNALIS RES LTD (GB) | 2003-12-17 | — | — | EP | disclosed |
| US-6531511-B1 | N-methyl aspartate receptor antagonist | VERNALIS RESEARCH LIMITED (GB) | 2003-03-11 | — | — | US | disclosed |
| EP-1143964-A1 | 2-ADAMANTANEMETHANAMINE COMPOUNDS FOR TREATING ABNORMALITIES IN GLUTAMATERGIC TRANSMISSION | VERNALIS RESEARCH LIMITED (GB) | 2001-10-17 | — | — | EP | disclosed |
| US-6262106-B1 | Adamantanecarboximidamide derivatives and their use as NMDA antagonists | VERNALIS RESEARCH LIMITED (GB) | 2001-07-17 | — | — | US | disclosed |
| EP-1051392-A1 | ADAMANTANECARBOXIMIDAMIDE DERIVATIVES AND THEIR USE AS NMDA ANTAGONISTS | VERNALIS RESEARCH LIMITED (GB) | 2000-11-15 | — | — | EP | disclosed |
| WO-2000044371-A1 | 2-ADAMANTANEMETHANAMINE COMPOUNDS FOR TREATING ABNORMALITIES IN GLUTAMATERGIC TRANSMISSION | VERNALIS RESEARCH LIMITED (GB) | 2000-08-03 | — | — | WO | disclosed |
| WO-1999038841-A1 | ADAMANTANECARBOXIMIDAMIDE DERIVATIVES AND THEIR USE AS NMDA ANTAGONISTS | VERNALIS RESEARCH LIMITED (GB) | 1999-08-05 | — | — | WO | disclosed |