Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 6/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.30 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.30 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.30 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.30 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.30 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.30 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.30 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.30 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL790543 | 0.77 | SIGMAR1 (0.37) | HSD11B1HDAC4P2RX7TSHRACHE | |
| SCHEMBL6897685 | 0.74 | HSD11B1 (0.38) | HSD11B1HDAC4P2RX7SIGMAR1OPRM1 | |
| SCHEMBL6682404 | 0.72 | HSD11B1 (0.50) | HSD11B1 | |
| SCHEMBL6897911 | 0.70 | ALDH1A1 (0.35) | HSD11B1HDAC4P2RX7TSHRALDH1A1 | |
| Hydrochloric Acid SCHEMBL6899621 | 0.69 | HSD11B1 (0.40) | HSD11B1P2RX7SIGMAR1GRIN2DGRIN3B | |
| SCHEMBL6686003 | 0.68 | HSD11B1 (0.40) | HSD11B1P2RX7SIGMAR1GRIN2DGRIN3B | |
| SCHEMBL6933296 | 0.68 | SIGMAR1 (0.37) | HSD11B1HDAC4P2RX7SIGMAR1GRIN2D | |
| SCHEMBL9721521 | 0.67 | HSD11B1 (0.42) | HSD11B1P2RX7TSHRALDH1A1SIGMAR1 | |
| Hydrochloric Acid SCHEMBL6685252 | 0.67 | HSD11B1 (0.39) | HSD11B1P2RX7SIGMAR1GRIN2DGRIN3B | |
| Hydrochloric Acid SCHEMBL6930722 | 0.67 | SIGMAR1 (0.36) | HSD11B1HDAC4P2RX7SIGMAR1GRIN2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003064372-A1 | 2-ADAMANTYLALKYLAMINES AND THEIR USE IN THE TREATMENT OF CONDITIONS GENERALLY ASSOCIATED WITH ABNORMALITIES IN GLUTAMATERGIC TRANSMISSION | VERNALIS RESEARCH LIMITED (GB) | 2003-08-07 | — | — | WO | disclosed |