Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7643733 | 0.84 | ALDH1A1 (0.36) | CYP1A2CYP2A6KDM4EMAPTPABPC1 | |
| Hydrochloric Acid SCHEMBL28553655 | 0.82 | GAA (0.33) | KDM4ESMN1; SMN2 | |
| SCHEMBL7252931 | 0.81 | CYP1A2 (0.43) | CYP1A2CYP2A6KDM4EMAPTPABPC1 | |
| Hydrochloric Acid SCHEMBL4078640 | 0.81 | CYP11B1 (0.31) | — | |
| Hydrochloric Acid SCHEMBL7807224 | 0.79 | PTPN1 (0.35) | CYP1A2CYP2A6KDM4EMAPTSMN1; SMN2 | |
| SCHEMBL7996884 | 0.79 | CYP1A2 (0.42) | CYP1A2CYP2A6KDM4EMAPTPABPC1 | |
| SCHEMBL7645586 | 0.78 | CYP1A2 (0.41) | CYP1A2CYP2A6KDM4EMAPTPABPC1 | |
| Hydrochloric Acid SCHEMBL7196886 | 0.77 | CYP1A2 (0.40) | CYP1A2CYP2A6 | |
| Hydrochloric Acid SCHEMBL27880512 | 0.77 | ALDH1A1 (0.36) | — | |
| Hydrochloric Acid SCHEMBL21980376 | 0.76 | CYP1A2 (0.35) | CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6794019-B2 | MOLDING MATERIALS; USING COORDINATION CATALYSTS | BASELL POLYOLEFINE GMBH (DE) | 2004-09-21 | — | — | US | disclosed |
| EP-0942006-B1 | Catalyst for olefin polymer production and process for olefin polymer production employing the catalyst | TOSOH CORP (JP) | 2003-06-04 | — | — | EP | disclosed |
| US-20020182428-A1 | FILMS AND LAYERS | EQUISTAR CHEMICALS, LP | 2002-12-05 | — | — | US | disclosed |
| EP-1141034-A2 | BRIDGED METAL COMPLEXES FOR GAS PHASE POLYMERIZATIONS | BP Chemicals Limited (GB) | 2001-10-10 | — | — | EP | disclosed |
| EP-1119575-A1 | BRIDGED METAL COMPLEXES | THE DOW CHEMICAL COMPANY (US) | 2001-08-01 | — | — | EP | disclosed |
| WO-2000020462-A2 | BRIDGED METAL COMPLEXES FOR GAS PHASE POLYMERIZATIONS | BP CHEMICALS LIMITED (GB) | 2000-04-13 | — | — | WO | disclosed |
| WO-2000020426-A1 | BRIDGED METAL COMPLEXES | THE DOW CHEMICAL COMPANY (US) | 2000-04-13 | — | — | WO | disclosed |