Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.32 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.34 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | LCK | P06239 | 1/20 | 0.32 |
| ▸ | FYN | P06241 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7807237 | 0.84 | CYP3A4 (0.30) | TSHRHPGDHSD17B10CYP3A4L3MBTL1 | |
| Hydrochloric Acid SCHEMBL6898339 | 0.84 | CYP1A2 (0.41) | CYP1A2CYP2A6MAPTKDM4EPABPC1 | |
| Hydrochloric Acid SCHEMBL7643736 | 0.80 | CYP1A2 (0.33) | TSHRHPGDHSD17B10CYP3A4L3MBTL1 | |
| Hydrochloric Acid SCHEMBL7807224 | 0.77 | PTPN1 (0.35) | ALDH1A1TSHRHPGDHSD17B10L3MBTL1 | |
| Hydrochloric Acid SCHEMBL7807249 | 0.75 | CYP1A2 (0.34) | CYP1A2CYP2A6 | |
| Hydrochloric Acid SCHEMBL7196886 | 0.74 | CYP1A2 (0.40) | CYP1A2CYP2A6 | |
| Hydrochloric Acid SCHEMBL28553655 | 0.73 | GAA (0.33) | ALDH1A1TSHRRAB9AATMACHE | |
| Hydrochloric Acid SCHEMBL8169170 | 0.71 | PSMB5 (0.32) | — | |
| Hydrochloric Acid SCHEMBL4078640 | 0.69 | CYP11B1 (0.31) | — | |
| Hydrochloric Acid SCHEMBL27880512 | 0.69 | ALDH1A1 (0.36) | ALDH1A1TSHRL3MBTL1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020182428-A1 | FILMS AND LAYERS | EQUISTAR CHEMICALS, LP | 2002-12-05 | — | — | US | disclosed |
| US-20010007009-A1 | Transition metal catalyzed polymerization of olefinic monomers in a water-containing polymerization medium | BASF AKTIENGESELLSCHAFT (DE) | 2001-07-05 | — | — | US | disclosed |