Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Acridine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLG known ✓ | P00747 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | THRB | P10828 | 2/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.48 |
| ▸ | BLM | P54132 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | LTB4R | Q15722 | 3/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Naphthalene SCHEMBL6898872 | 0.85 | LMNA (0.68) | ALDH1A1KMT2AMEN1LMNATHRB | |
| Acridine SCHEMBL17892439 | 0.84 | PPARG (0.53) | ALDH1A1KMT2AMEN1ALOX15MAPT | |
| Acridine SCHEMBL28897857 | 0.83 | ALDH1A1 (0.62) | ALDH1A1KMT2AMEN1LMNANPSR1 | |
| Acridine SCHEMBL27894463 | 0.83 | MAPT (0.68) | ALDH1A1KMT2AMEN1LMNAMAPT | |
| Acridine SCHEMBL9542382 | 0.81 | AKR1B1 (0.50) | ALDH1A1KMT2AMEN1ALOX15MAPT | |
| Acridine SCHEMBL9614417 | 0.76 | ALDH1A1 (0.58) | ALDH1A1KMT2AMEN1LMNACYP2D6 | |
| Acridine SCHEMBL4854060 | 0.75 | ALDH1A1 (0.68) | ALDH1A1KMT2AMEN1LMNAMAPT | |
| 5-Aminovaleric Acid SCHEMBL11669034 | 0.75 | NFKB1 (0.89) | ALDH1A1KMT2AMEN1LMNATHRB | |
| Behenic Acid SCHEMBL31536707 | 0.73 | GPR84 (0.61) | ALDH1A1KMT2AMEN1LMNAALOX15 | |
| Benzamide SCHEMBL14574628 | 0.73 | LMNA (0.61) | ALDH1A1KMT2AMEN1LMNATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120035320-A1 | POLYACRIDINE NUCLEIC ACID DELIVERY PEPTIDE COMPLEXES | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 2012-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120035320-A1 | POLYACRIDINE NUCLEIC ACID DELIVERY PEPTIDE COMPLEXES | NUP205, PABPC1, SARNP | PLG 1586/4885ALDH1A1 3315/4885KMT2A 2891/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.