Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGM2 | P21980 | 14/20 | 0.50 |
| ▸ | F13A1 | P00488 | 13/20 | 0.50 |
| ▸ | TGM1 | P22735 | 13/20 | 0.50 |
| ▸ | IKBKB | O14920 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.45 |
| ▸ | JAK1 | P23458 | 1/20 | 0.45 |
| ▸ | TYK2 | P29597 | 1/20 | 0.45 |
| ▸ | JAK3 | P52333 | 1/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.45 |
| ▸ | NAMPT | P43490 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14102424 | 0.76 | HTR6 (0.51) | — | |
| SCHEMBL14375100 | 0.76 | SLC12A2 (0.52) | — | |
| SCHEMBL14102431 | 0.76 | GBA1 (0.42) | IKBKBJAK2ROCK2JAK1TYK2 | |
| SCHEMBL1874118 | 0.76 | POLB (0.66) | POLB | |
| SCHEMBL4743569 | 0.76 | GBA1 (0.59) | POLB | |
| SCHEMBL9568839 | 0.73 | TGM2 (0.65) | TGM2F13A1TGM1POLB | |
| SCHEMBL14282764 | 0.72 | KMT2A (0.58) | IKBKBJAK2ROCK2JAK1TYK2 | |
| SCHEMBL1688072 | 0.72 | LMNA (0.60) | TGM2F13A1TGM1NAMPT | |
| SCHEMBL1688071 | 0.71 | TGM2 (0.61) | TGM2F13A1TGM1NAMPTPOLB | |
| SCHEMBL1874978 | 0.70 | TGM2 (0.55) | TGM2F13A1TGM1NAMPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011060321-A1 | TRANSGLUTAMINASE TG2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF | CHDI, INC. (US) | 2011-05-19 | — | — | WO | disclosed |