Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | LTA4H | P09960 | 2/20 | 0.45 |
| ▸ | CA4 | P22748 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | TTR | P02766 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5372849 | 0.86 | TSHR (0.44) | ALDH1A1MAPK1HTTL3MBTL1LTA4H | |
| SCHEMBL4596133 | 0.82 | MAPK1 (0.59) | ALDH1A1MAPK1HTTL3MBTL1LTA4H | |
| SCHEMBL1627615 | 0.80 | SMN1; SMN2 (0.50) | ALDH1A1MAPK1HTTL3MBTL1CA4 | |
| SCHEMBL29732515 | 0.80 | SMN1; SMN2 (0.50) | ALDH1A1MAPK1HTTL3MBTL1CA4 | |
| SCHEMBL9139036 | 0.79 | HTT (0.50) | ALDH1A1MAPK1HTTL3MBTL1LTA4H | |
| SCHEMBL27468784 | 0.78 | DPP4 (0.54) | ALDH1A1MAPK1HTTL3MBTL1LTA4H | |
| SCHEMBL130304 | 0.78 | LTA4H (0.52) | ALDH1A1MAPK1HTTL3MBTL1LTA4H | |
| SCHEMBL11165658 | 0.77 | SLC6A2 (0.47) | ALDH1A1MAPK1HTTL3MBTL1LTA4H | |
| SCHEMBL14857881 | 0.77 | LTA4H (0.42) | ALDH1A1MAPK1HTTL3MBTL1LTA4H | |
| SCHEMBL17472520 | 0.77 | ALDH1A1 (0.57) | ALDH1A1MAPK1HTTL3MBTL1LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1443923-A1 | HYDROXY SUBSTITUTED AMIDES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | Elan Pharmaceuticals, Inc. (US) | 2004-08-11 | — | — | EP | disclosed |
| WO-2003037325-A1 | HYDROXY SUBSTITUTED AMIDES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | ELAN PHARMACEUTICALS, INC. (US) | 2003-05-08 | — | — | WO | disclosed |