Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | COMT | P21964 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14329776 | 0.84 | NPC1 (0.42) | NPC1GAAMAPK1RAB9A | |
| SCHEMBL15796727 | 0.75 | COMT (0.42) | NPC1GAAMAPK1RAB9ACOMT | |
| SCHEMBL12827565 | 0.75 | GRM5 (0.37) | NPC1GAAMAPK1RAB9ACOMT | |
| SCHEMBL13330942 | 0.75 | MAPK1 (0.41) | NPC1GAAMAPK1RAB9ACOMT | |
| SCHEMBL9688066 | 0.73 | NPC1 (0.31) | NPC1GAAMAPK1RAB9A | |
| SCHEMBL13331974 | 0.73 | NPC1 (0.40) | NPC1GAAMAPK1RAB9ACOMT | |
| SCHEMBL22774947 | 0.73 | NPC1 (0.40) | NPC1GAAMAPK1RAB9ACOMT | |
| SCHEMBL2175079 | 0.73 | ALDH1A1 (0.48) | NPC1GAARAB9A | |
| Hydrochloric Acid SCHEMBL10987975 | 0.71 | ALDH1A1 (0.47) | NPC1GAARAB9A | |
| SCHEMBL7616115 | 0.70 | NPC1 (0.34) | NPC1GAAMAPK1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1031696-A | Method by the formaldehyde synthetic glycerine | BP CHEM INT LTD (GB) | 1989-03-15 | — | — | CN | claimed |
| US-20120329811-A1 | Heteroaromatic Derivatives and their use as positive allosteric modulators of metabotropic glutamate receptors | BOLEA CHRISTELLE (CH) | 2012-12-27 | — | — | US | disclosed |
| US-20110178101-A1 | DUAL-ACTING THIOPHENE, PYRROLE, THIAZOLE AND FURAN ANTIHYPERTENSIVE AGENTS | THERAVANCE BIOPHARMA R&D IP, LLC | 2011-07-21 | — | — | US | disclosed |
| US-20100144756-A1 | NOVEL HETEROAROMATIC DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | ADDEX PHARMA SA (CH) | 2010-06-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110178101-A1 | DUAL-ACTING THIOPHENE, PYRROLE, THIAZOLE AND FURAN ANTIHYPERTENSIVE AGENTS | REN, AGTR1, AGTR2 | NPC1 2475/4885GAA 2685/4885MAPK1 2243/4885 |
| US-20100144756-A1 | NOVEL HETEROAROMATIC DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | GRM3, GRM4, GRM2 | NPC1 2378/4885GAA 3141/4885MAPK1 1794/4885 |
| US-20120329811-A1 | Heteroaromatic Derivatives and their use as positive allosteric modulators of metabotropic glutamate receptors | GRM3, GRM4, GRM1 | NPC1 2504/4885GAA 3066/4885MAPK1 1758/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.