Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.36 |
| ▸ | EIF4A1 | P60842 | 5/20 | 0.33 |
| ▸ | RARB | P10826 | 6/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | RARA | P10276 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 2/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6903263 | 0.96 | EIF4A1 (0.36) | HSD11B1EIF4A1 | |
| Hydrochloric Acid SCHEMBL6901876 | 0.92 | ALDH1A1 (0.30) | ALDH1A1 | |
| Hydrochloric Acid SCHEMBL6898160 | 0.89 | RARB (0.33) | HSD11B1RARBMEN1ALDH1A1RARA | |
| Hydrochloric Acid SCHEMBL6903886 | 0.89 | NQO2 (0.36) | ALDH1A1 | |
| Hydrochloric Acid SCHEMBL6900458 | 0.89 | ALOX5 (0.34) | HSD11B1RARBMEN1ALDH1A1RARA | |
| Hydrochloric Acid SCHEMBL6901874 | 0.89 | ALOX5 (0.32) | HSD11B1RARBMEN1ALDH1A1RARA | |
| SCHEMBL6902721 | 0.85 | HSD11B1 (0.37) | HSD11B1EIF4A1RARBMEN1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL6904729 | 0.85 | HSD11B1 (0.32) | HSD11B1ALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL6902799 | 0.84 | CHRM2 (0.36) | ALDH1A1 | |
| Hydrochloric Acid SCHEMBL6903364 | 0.84 | CHRM2 (0.34) | ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1033371-B1 | Transition metal compound, catalyst system, process for the preparation thereof and its use for the polymerization of olefins | BASELL POLYOLEFINE GMBH (DE) | 2004-01-28 | — | — | EP | claimed |
| US-6458982-B1 | CATALYST SYSTEM COMPRISING AT LEAST ONE METALLOCENE AND AT LEAST ONE COCATALYST. ON SUPPORT. | TARGOR GMBH (DE) | 2002-10-01 | — | — | US | disclosed |