Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.32 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.32 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6902799 | 0.88 | CHRM2 (0.36) | ALDH1A1HPGDHSD17B10CHRM2CHRM4 | |
| Hydrochloric Acid SCHEMBL6902711 | 0.86 | MAOA (0.32) | ALDH1A1KDM4EMAPTHPGDSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL6903405 | 0.84 | ADORA2A (0.33) | ALDH1A1KDM4EMAPTSMN1; SMN2HSD17B10 | |
| Hydrochloric Acid SCHEMBL6902739 | 0.83 | HTR6 (0.34) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL6902347 | 0.82 | ALDH1A1 (0.39) | ALDH1A1KDM4EMAPTHPGDSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL6901342 | 0.81 | HTR6 (0.33) | — | |
| Hydrochloric Acid SCHEMBL6902074 | 0.81 | HPGD (0.34) | ALDH1A1KDM4EMAPTHPGDSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7061934 | 0.81 | KDM4E (0.33) | ALDH1A1KDM4EMAPTHPGDSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL6902770 | 0.80 | CA12 (0.36) | ALDH1A1KDM4EMAPTHPGDSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL6903886 | 0.80 | NQO2 (0.36) | ALDH1A1HPGDCHRM2CHRM4CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1033371-B1 | Transition metal compound, catalyst system, process for the preparation thereof and its use for the polymerization of olefins | BASELL POLYOLEFINE GMBH (DE) | 2004-01-28 | — | — | EP | claimed |
| US-6458982-B1 | CATALYST SYSTEM COMPRISING AT LEAST ONE METALLOCENE AND AT LEAST ONE COCATALYST. ON SUPPORT. | TARGOR GMBH (DE) | 2002-10-01 | — | — | US | disclosed |