Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1659910 | 0.92 | ALDH1A1 (0.32) | POLB | |
| SCHEMBL1659951 | 0.90 | SCN9A (0.33) | — | |
| SCHEMBL14717715 | 0.90 | PTGS2 (0.34) | — | |
| SCHEMBL14718410 | 0.90 | BRD4 (0.31) | — | |
| SCHEMBL14718241 | 0.90 | LMNA (0.34) | — | |
| SCHEMBL1661812 | 0.90 | CETP (0.37) | — | |
| SCHEMBL14730952 | 0.90 | PKM (0.33) | — | |
| SCHEMBL14718606 | 0.88 | CETP (0.31) | — | |
| SCHEMBL6903342 | 0.88 | PTPN5 (0.33) | — | |
| SCHEMBL1660500 | 0.88 | MAOA (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011046774-A1 | DIARYL ETHER DERIVATIVES AS NOTCH SPARING GAMMA SECRETASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2011-04-21 | — | — | WO | disclosed |