SCHEMBL6903018

SCHEMBL6903018

CCCCOC(=O)C1CC(CCC(c2ccccc2)c2ccccc2)CCN1C(=O)C(=O)C(C)(C)CC

nearest known ligand 0.66

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
FKBP1A P62942 20/20 0.66

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7605473 0.93 FKBP1A (0.55) FKBP1A
SCHEMBL7253232 0.83 FKBP1A (0.88) FKBP1A
SCHEMBL8796618 0.80 FKBP1A (0.96) FKBP1A
SCHEMBL7246458 0.75 FKBP1A (0.71) FKBP1A
SCHEMBL7432524 0.75 FKBP1A (0.62) FKBP1A
SCHEMBL5834555 0.73 FKBP1A (1.00) FKBP1A
SCHEMBL7396367 0.73 FKBP1A (1.00) FKBP1A
SCHEMBL7249394 0.73 FKBP1A (0.89) FKBP1A
SCHEMBL7980344 0.72 FKBP1A (0.69) FKBP1A
SCHEMBL7980342 0.72 FKBP1A (0.69) FKBP1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-2002522485-A 2002-07-23 JP claimed
EP-1109554-A2 PIPECOLIC ACID DERIVATIVES FOR VISION AND MEMORY DISORDERS GPI NIL Holdings, Inc. (US) 2001-06-27 EP claimed
WO-2000009109-A2 PIPECOLIC ACID DERIVATIVES FOR VISION AND MEMORY DISORDERS GPI NIL HOLDINGS, INC. (US) 2000-02-24 WO claimed
EP-1083874-B1 Use of a compound for the preparation of a medicament for treating alopecia or promoting hair growth in an animal GUILFORD PHARM INC (US) 2004-01-02 EP disclosed
US-6395758-B1 VISION DEFECTS GPI NIL HOLDINGS, INC. 2002-05-28 US disclosed
US-20020037924-A1 Small molecule carbamate or urea hair growth compositions and uses GPI NIL HOLDINGS, INC. (US) 2002-03-28 US disclosed
US-6335348-B1 ADMINISTERING PIPECOLIC ACID DERIVATIVE AS COGNITION ACTIVATOR AND TO TREAT EYE AND NERVOUS SYSTEM DISORDERS GPI NIL HOLDINGS, INC. 2002-01-01 US disclosed
US-6333340-B1 SULFONAMIDES WITH OXO, ESTER OR AMIDE GROUPS FOR VISION DEFECTS AND COGNITION ACTIVATORS GPI NIL HOLDINGS, INC. 2001-12-25 US disclosed
US-20010036952-A1 Small molecule pipecolic acid derivative hair growth compositions and uses GPI NIL HOLDINGS, INC. (US) 2001-11-01 US disclosed
US-20010029261-A1 Small molecule sulfonamide hair growth compositions and uses GUILFORD PHARMACEUTICALS INC. 2001-10-11 US disclosed
EP-1104402-A1 PIPECOLIC ACID DERIVATIVES AND THEIR USE FOR VISION AND MEMORY DISORDERS GPI NIL Holdings, Inc. (US) 2001-06-06 EP disclosed
US-6194440-B1 Small molecule carbamate or urea hair growth compositions and uses GPI NIL HOLDINGS, INC. 2001-02-27 US disclosed
US-6191125-B1 ALOPECIA THERAPY GPI NIL HOLDINGS, INC. 2001-02-20 US disclosed
US-6187796-B1 ALOPECIA TREATMENT; IMMUNOPHILIN AFFINITY GPI NIL HOLDINGS, INC. 2001-02-13 US disclosed
WO-2000009484-A1 PIPECOLIC ACID DERIVATIVES AND THEIR USE FOR VISION AND MEMORY DISORDERS GPI NIL HOLDINGS, INC. (US) 2000-02-24 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020037924-A1 Small molecule carbamate or urea hair growth compositions and uses SHH, CPS1, SLC14A1 FKBP1A 1457/4885
US-20010036952-A1 Small molecule pipecolic acid derivative hair growth compositions and uses PIP5K1C, PIP4K2C, PIP5K1A FKBP1A 632/4885
US-20010029261-A1 Small molecule sulfonamide hair growth compositions and uses PSAP, SHH, SPTSSB FKBP1A 152/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.