Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 7/20 | 0.53 |
| ▸ | MMP13 | P45452 | 10/20 | 0.52 |
| ▸ | MMP2 | P08253 | 7/20 | 0.52 |
| ▸ | MMP9 | P14780 | 7/20 | 0.52 |
| ▸ | MMP8 | P22894 | 5/20 | 0.52 |
| ▸ | MMP3 | P08254 | 2/20 | 0.52 |
| ▸ | MMP14 | P50281 | 2/20 | 0.52 |
| ▸ | MMP16 | P51512 | 2/20 | 0.52 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.52 |
| ▸ | BMP1 | P13497 | 2/20 | 0.45 |
| ▸ | MMP7 | P09237 | 1/20 | 0.45 |
| ▸ | MMP12 | P39900 | 1/20 | 0.45 |
| ▸ | LTA4H | P09960 | 1/20 | 0.45 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5243658 | 0.81 | MMP1 (0.56) | MMP1MMP13MMP2MMP9MMP8 | |
| SCHEMBL1965951 | 0.79 | MMP1 (0.53) | MMP1MMP13MMP2MMP9MMP8 | |
| SCHEMBL231737 | 0.74 | MMP1 (0.55) | MMP1MMP13MMP2MMP9MMP8 | |
| SCHEMBL8003329 | 0.73 | MMP2 (0.53) | MMP1MMP13MMP2MMP9MMP8 | |
| SCHEMBL26770077 | 0.73 | ESR1 (0.49) | MMP1MMP13MMP2MMP9MMP8 | |
| SCHEMBL27726010 | 0.73 | MMP1 (0.45) | MMP1MMP13MMP2MMP9MMP8 | |
| SCHEMBL27517932 | 0.73 | SMN1; SMN2 (0.48) | MMP1MMP13MMP2MMP9MMP3 | |
| SCHEMBL8012383 | 0.72 | BMP1 (0.53) | MMP1MMP13MMP2MMP9MMP8 | |
| SCHEMBL8435001 | 0.71 | MMP2 (0.72) | MMP1MMP13MMP2MMP9MMP8 | |
| SCHEMBL7537813 | 0.71 | MMP9 (0.62) | MMP1MMP13MMP2MMP9MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1233948-A4 | STABLE POLYMORPH OF N-(3-ETHYNYLPHENYLAMINO)-6,7-BIS(2-METHOXYETHOXY)-4-QUINAZOLINAMINE HYDROCHLORIDE, METHODS OF PRODUCTION, AND PHARMACEUTICAL USES THEREOF | OSI PHARM INC (US) | 2004-01-28 | — | — | EP | disclosed |
| EP-1233948-A1 | STABLE POLYMORPH OF N-(3-ETHYNYLPHENYLAMINO)-6,7-BIS(2-METHOXYETHOXY)-4-QUINAZOLINAMINE HYDROCHLORIDE, METHODS OF PRODUCTION, AND PHARMACEUTICAL USES THEREOF | OSI Pharmaceuticals, Inc. (US) | 2002-08-28 | — | — | EP | disclosed |
| WO-2001034574-A1 | STABLE POLYMORPH OF N-(3-ETHYNYLPHENYLAMINO)-6,7-BIS(2-METHOXYETHOXY)-4-QUINAZOLINAMINE HYDROCHLORIDE, METHODS OF PRODUCTION, AND PHARMACEUTICAL USES THEREOF | OSI PHARMACEUTICALS, INC. (US) | 2001-05-17 | — | — | WO | disclosed |