Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR88 | Q9GZN0 | 12/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.32 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.32 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.32 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6903366 | 0.94 | BRS3 (0.36) | GPR88NPC1RAB9AKMT2AALDH1A1 | |
| Hydrochloric Acid SCHEMBL6902674 | 0.92 | HTR2A (0.38) | NPC1RAB9AKMT2AALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL6902388 | 0.91 | NPC1 (0.36) | NPC1RAB9AKMT2AALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL6899139 | 0.85 | SYK (0.40) | NPC1RAB9AKMT2AALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL6904002 | 0.85 | NPC1 (0.42) | NPC1RAB9AKMT2AALDH1A1MAPT | |
| SCHEMBL6902715 | 0.85 | GPR88 (0.38) | GPR88NPC1RAB9AKMT2AALDH1A1 | |
| Hydrochloric Acid SCHEMBL6904743 | 0.83 | ALDH1A1 (0.37) | NPC1RAB9AKMT2AALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL6904678 | 0.83 | ALDH1A1 (0.33) | GPR88NPC1RAB9AKMT2AALDH1A1 | |
| Hydrochloric Acid SCHEMBL6904019 | 0.82 | ALDH1A1 (0.36) | NPC1RAB9AKMT2AALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL6898055 | 0.82 | NPC1 (0.36) | NPC1RAB9AKMT2AALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1033371-B1 | Transition metal compound, catalyst system, process for the preparation thereof and its use for the polymerization of olefins | BASELL POLYOLEFINE GMBH (DE) | 2004-01-28 | — | — | EP | claimed |
| US-6458982-B1 | CATALYST SYSTEM COMPRISING AT LEAST ONE METALLOCENE AND AT LEAST ONE COCATALYST. ON SUPPORT. | TARGOR GMBH (DE) | 2002-10-01 | — | — | US | disclosed |