Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6057962 | 0.89 | CES1 (0.31) | CES1 | |
| Hydrochloric Acid SCHEMBL622158 | 0.87 | DHFR (0.33) | ALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL4062027 | 0.84 | ALDH1A1 (0.34) | ALDH1A1CYP1A2HPGDHSD17B10 | |
| Hydrochloric Acid SCHEMBL6754810 | 0.83 | HDAC4 (0.33) | — | |
| Hydrochloric Acid SCHEMBL4063465 | 0.81 | HDAC4 (0.36) | CYP1A2 | |
| Hydrochloric Acid SCHEMBL481289 | 0.80 | PDCD1 (0.31) | HTR1AHTR7 | |
| Hydrochloric Acid SCHEMBL6439096 | 0.80 | PDCD1 (0.31) | HTR1AHTR7 | |
| Hydrochloric Acid SCHEMBL5608847 | 0.80 | — | — | |
| Hydrochloric Acid SCHEMBL6464432 | 0.80 | PDCD1 (0.31) | HTR1AHTR7 | |
| Hydrochloric Acid SCHEMBL4318451 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0791626-B1 | RESIN COMPOSITIONS AND USE THEREOF | MITSUI CHEMICALS INC (JP) | 2004-06-09 | — | — | EP | disclosed |
| EP-0751156-B1 | Ethylene copolymer rubber, vulcanizable rubber composition containing the copolymer rubber, and process for preparing the copolymer rubber | MITSUI CHEMICALS INC (JP) | 2001-09-05 | — | — | EP | disclosed |