Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethane SCHEMBL8832631 | 0.83 | PNMT (0.32) | PNMTNPC1RAB9A | |
| Hydrochloric Acid SCHEMBL6448739 | 0.82 | PNMT (0.36) | PNMTNPC1RAB9A | |
| Hydrochloric Acid SCHEMBL6445368 | 0.80 | PNMT (0.32) | PNMTNPC1RAB9A | |
| Hydrochloric Acid SCHEMBL7553835 | 0.76 | PNMT (0.37) | PNMTNPC1RAB9A | |
| Hydrochloric Acid SCHEMBL618215 | 0.74 | PNMT (0.50) | PNMTNPC1RAB9A | |
| Hydrochloric Acid SCHEMBL29479988 | 0.74 | PNMT (0.50) | PNMTNPC1RAB9A | |
| Hydrochloric Acid SCHEMBL10513406 | 0.73 | PNMT (0.49) | PNMTNPC1RAB9A | |
| Hydrochloric Acid SCHEMBL6900784 | 0.72 | — | — | |
| Hydrochloric Acid SCHEMBL5069355 | 0.72 | PNMT (0.34) | PNMTNPC1RAB9A | |
| Hydrochloric Acid SCHEMBL7549004 | 0.72 | PNMT (0.37) | PNMTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5824620-A | ZIRCONIUM COMPLEX CATALYST USED TO POLYMERIZE ETHYLENE | REPSOL QUIMICA S.A. (ES) | 1998-10-20 | — | — | US | claimed |
| EP-0757992-B1 | Heterogenous metallocene catalysts and use thereof in olefin polymerization process | REPSOL QUIMICA SA (ES) | 2004-03-03 | — | — | EP | disclosed |
| US-6133187-A | A CATALYST COMPONENT OBTAINED BY CONTACTING A METALLOCENE COMPOUND WITH AN INORGANIC SUPPORT FORMING STRONG BOND | REPSOL QUIMICA S.A. (ES) | 2000-10-17 | — | — | US | disclosed |
| US-5824620-A | ZIRCONIUM COMPLEX CATALYST USED TO POLYMERIZE ETHYLENE | REPSOL QUIMICA S.A. (ES) | 1998-10-20 | — | — | US | disclosed |
| EP-0757992-A1 | Heterogenous metallocene catalysts and use thereof in olefin polymerization process | REPSOL QUIMICA S.A. (ES) | 1997-02-12 | — | — | EP | disclosed |