Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | PDE5A | O76074 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3905489 | 0.86 | CA12 (0.46) | KDM4EALDH1A1HSD17B10HPGDSMN1; SMN2 | |
| SCHEMBL30113113 | 0.84 | CA12 (0.49) | KDM4EALDH1A1HSD17B10HPGDSMN1; SMN2 | |
| SCHEMBL18796365 | 0.84 | CA12 (0.49) | KDM4EALDH1A1HSD17B10HPGDSMN1; SMN2 | |
| SCHEMBL29232338 | 0.83 | HSD11B1 (0.40) | KDM4EALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL10923350 | 0.82 | CA12 (0.46) | ALDH1A1PDE4BPTPN1HTTNPSR1 | |
| SCHEMBL6908438 | 0.81 | GAA (0.41) | KDM4ESMN1; SMN2PDE4BPTPN1CYP2C9 | |
| SCHEMBL6908220 | 0.80 | ABCG2 (0.65) | PDE4BMAPT | |
| SCHEMBL4020110 | 0.79 | NPC1 (0.51) | ALDH1A1HPGDSMN1; SMN2MEN1KMT2A | |
| SCHEMBL7157436 | 0.78 | LMNA (0.41) | PDE4BPTPN1KMT2AHTTLMNA | |
| SCHEMBL15100426 | 0.78 | PTPN1 (0.43) | ALDH1A1HPGDPDE4BPTPN1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9309455-B2 | Indeno-fused ring compounds | TRANSITIONS OPTICAL, INC. (US) | 2016-04-12 | — | — | US | disclosed |
| US-20140166948-A1 | INDENO-FUSED RING COMPOUNDS | TRANSITIONS OPTICAL LIMITED (IE) | 2014-06-19 | — | — | US | disclosed |
| US-8545984-B2 | Photochromic compounds and compositions | TRANSITIONS OPTICAL, INC. (US) | 2013-10-01 | — | — | US | disclosed |
| US-20120126185-A1 | INDENO-FUSED RING COMPOUNDS | TRANSITIONS OPTICAL, INC. (US) | 2012-05-24 | — | — | US | disclosed |
| US-20110129678-A1 | Photochromic compounds and compositions | TRANSITIONS OPTICAL, INC. (US) | 2011-06-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110129678-A1 | Photochromic compounds and compositions | CRY2, CRY1, PPOX | KDM4E 2937/4885ALDH1A1 1243/4885HSD17B10 1796/4885 |
| US-20120126185-A1 | INDENO-FUSED RING COMPOUNDS | CRY2, SQOR, INTS6 | KDM4E 464/4885ALDH1A1 498/4885HSD17B10 2142/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.