Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 9/20 | 1.00 |
| ▸ | PKM | P14618 | 1/20 | 0.76 |
| ▸ | RECQL | P46063 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | CA1 | P00915 | 1/20 | 0.55 |
| ▸ | CA2 | P00918 | 1/20 | 0.55 |
| ▸ | CA4 | P22748 | 1/20 | 0.55 |
| ▸ | CA9 | Q16790 | 1/20 | 0.55 |
| ▸ | CES2 | O00748 | 1/20 | 0.54 |
| ▸ | CES1 | P23141 | 1/20 | 0.54 |
| ▸ | GSK3B | P49841 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28538245 | 0.95 | HSD11B1 (0.91) | HSD11B1PKMRECQLALDH1A1NPC1 | |
| SCHEMBL30008266 | 0.85 | HSD11B1 (0.74) | HSD11B1PKMALDH1A1CES2CES1 | |
| SCHEMBL28538242 | 0.84 | HSD11B1 (0.72) | HSD11B1PKMRECQLCA1CA2 | |
| SCHEMBL452973 | 0.82 | HSD11B1 (0.77) | HSD11B1RECQLALDH1A1NPC1RAB9A | |
| SCHEMBL8415518 | 0.80 | HSD11B1 (0.67) | HSD11B1PKMCA1CA2CA4 | |
| SCHEMBL29609513 | 0.80 | HSD11B1 (0.74) | HSD11B1RECQLALDH1A1NPC1RAB9A | |
| Ammonia Solution, Strong SCHEMBL8416593 | 0.79 | HSD11B1 (0.65) | HSD11B1PKMCA1CA2CA4 | |
| SCHEMBL16660516 | 0.79 | HSD11B1 (0.73) | HSD11B1RECQLALDH1A1NPC1RAB9A | |
| SCHEMBL29236675 | 0.79 | HSD11B1 (0.73) | HSD11B1RECQLALDH1A1NPC1RAB9A | |
| SCHEMBL6202982 | 0.78 | HSD11B1 (1.00) | HSD11B1PKMRECQLALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6767926-B1 | Method for protecting normal cells from cytotoxicity of chemotherapeutic agents | TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2004-07-27 | — | — | US | disclosed |