Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.67 |
| ▸ | DRD4 | P21917 | 3/20 | 0.67 |
| ▸ | HTR7 | P34969 | 3/20 | 0.67 |
| ▸ | LMNA | P02545 | 2/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.65 |
| ▸ | HTT | P42858 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.64 |
| ▸ | DRD2 | P14416 | 3/20 | 0.64 |
| ▸ | DRD3 | P35462 | 2/20 | 0.64 |
| ▸ | HRH2 | P25021 | 1/20 | 0.64 |
| ▸ | HRH1 | P35367 | 1/20 | 0.64 |
| ▸ | GAA | P10253 | 2/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
| ▸ | USP2 | O75604 | 1/20 | 0.62 |
| ▸ | THRB | P10828 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11183243 | 0.99 | MAPK1 (0.67) | MAPK1ALDH1A1KDM4EDRD4HTR7 | |
| SCHEMBL11191164 | 0.91 | ALDH1A1 (0.78) | MAPK1ALDH1A1KDM4EDRD4HTR7 | |
| Hydrochloric Acid SCHEMBL11188368 | 0.90 | ALDH1A1 (0.77) | MAPK1ALDH1A1KDM4EDRD4HTR7 | |
| SCHEMBL6904661 | 0.89 | KDM4E (0.65) | MAPK1ALDH1A1KDM4EDRD4HTR7 | |
| SCHEMBL6904904 | 0.89 | USP2 (0.66) | MAPK1ALDH1A1KDM4EHTR7LMNA | |
| SCHEMBL11187366 | 0.88 | LMNA (0.61) | MAPK1ALDH1A1KDM4ELMNATDP1 | |
| SCHEMBL11191741 | 0.88 | KDM4E (0.80) | MAPK1ALDH1A1KDM4EDRD4HTR7 | |
| Hydrochloric Acid SCHEMBL11189440 | 0.88 | USP2 (0.65) | MAPK1ALDH1A1KDM4EHTR7LMNA | |
| SCHEMBL9720726 | 0.88 | KDM4E (0.79) | MAPK1ALDH1A1KDM4EDRD4HTR7 | |
| Hydrochloric Acid SCHEMBL11182928 | 0.87 | LMNA (0.60) | MAPK1ALDH1A1KDM4ELMNATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020052373-A1 | Combination treatment for dementia or cognitive deficits associated with alzheimer's disease and parkinson's disease | ZORN STEVIN H (US) | 2002-05-02 | — | — | US | claimed |
| EP-1201268-A2 | Combinations of D4 dopamine receptor antagonists with acetylcholine esterase inhibitors | Pfizer Products Inc. (US) | 2002-05-02 | — | — | EP | claimed |
| US-5965560-A | AS DOPAMINE ANTAGONISTS AND ANTIPSYCHOTIC AGENTS | WARNER-LAMBERT COMPANY (US) | 1999-10-12 | — | — | US | claimed |
| WO-1997041108-A1 | SUBSTITUTED PIPERAZINES AND PIPERIDINES AS CENTRAL NERVOUS SYSTEM AGENTS | WARNER-LAMBERT COMPANY (US) | 1997-11-06 | — | — | WO | claimed |
| US-4370330-A | Method of enhancing circulation with piperazines | MERZ & COMPANY (DE) | 1983-01-25 | — | — | US | claimed |
| US-20040048869-A1 | Combination treatment for depression, anxiety and psychosis | PFIZER INC | 2004-03-11 | — | — | US | disclosed |
| US-20020094986-A1 | Combination treatment for depression, anxiety and psychosis | PFIZER INC | 2002-07-18 | — | — | US | disclosed |
| EP-1213031-A2 | Combination treatment for depression, anxiety and psychosis comprising an antidepressant and/or anxiolytic and a D4 receptor antagonist | Pfizer Products Inc. (US) | 2002-06-12 | — | — | EP | disclosed |
| US-20020052373-A1 | Combination treatment for dementia or cognitive deficits associated with alzheimer's disease and parkinson's disease | ZORN STEVIN H (US) | 2002-05-02 | — | — | US | disclosed |
| EP-1201268-A2 | Combinations of D4 dopamine receptor antagonists with acetylcholine esterase inhibitors | Pfizer Products Inc. (US) | 2002-05-02 | — | — | EP | disclosed |
| US-6121267-A | ADMINISTERING DOPAMINE ANTAGONIST TO TREAT PSYCHOLOGICAL DISORDER, I.E., SCHIZOPHRENIA | WARNER-LAMBERT COMPANY (US) | 2000-09-19 | — | — | US | disclosed |
| US-5965560-A | AS DOPAMINE ANTAGONISTS AND ANTIPSYCHOTIC AGENTS | WARNER-LAMBERT COMPANY (US) | 1999-10-12 | — | — | US | disclosed |
| WO-1997041108-A1 | SUBSTITUTED PIPERAZINES AND PIPERIDINES AS CENTRAL NERVOUS SYSTEM AGENTS | WARNER-LAMBERT COMPANY (US) | 1997-11-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020094986-A1 | Combination treatment for depression, anxiety and psychosis | HTR4, CHRNA4, GRM4 | MAPK1 4265/4885ALDH1A1 710/4885KDM4E 3111/4885 |
| US-20020052373-A1 | Combination treatment for dementia or cognitive deficits associated with alzheimer's disease and parkinson's disease | ACHE, BCHE, CHRM4 | MAPK1 3917/4885ALDH1A1 860/4885KDM4E 1815/4885 |
| US-20040048869-A1 | Combination treatment for depression, anxiety and psychosis | HTR4, CHRNA4, GRM4 | MAPK1 4265/4885ALDH1A1 710/4885KDM4E 3111/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.