SCHEMBL6910596

SCHEMBL6910596

C[Si](C)(C)C1C=C(CC2=CC([Si](C)(C)C)c3ccccc32)c2ccccc21

nearest known ligand 0.36

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
HTR6 P50406 3/20 0.36
GPR3 P46089 1/20 0.32
HTR2A P28223 1/20 0.32
ACHE P22303 2/20 0.31
CHRM2 P08172 1/20 0.31
HTR1A P08908 1/20 0.31
ADRA2A P08913 1/20 0.31
CHRM1 P11229 1/20 0.31
DRD1 P21728 1/20 0.31
SLC6A2 P23975 1/20 0.31
SLC6A4 P31645 1/20 0.31
ADRA1A P35348 1/20 0.31
OPRM1 P35372 1/20 0.31
DRD3 P35462 1/20 0.31
SLC6A3 Q01959 1/20 0.31
HRH3 Q9Y5N1 1/20 0.31
SLC22A2 O15244 1/20 0.30
SLC22A3 O75751 1/20 0.30
BCHE P06276 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7781755 0.89 HTR6 (0.40) HTR6GPR3HTR2AACHECHRM2
SCHEMBL2463207 0.84 HRH3 (0.38) HTR6CHRM2CHRM1HRH3
SCHEMBL7542646 0.76 GPR3 (0.34) GPR3HTR2A
SCHEMBL29979921 0.74 GPR3 (0.33) GPR3
SCHEMBL7542082 0.74 GPR3 (0.33) GPR3
SCHEMBL8468840 0.74 HTR6 (0.39) HTR6
SCHEMBL7618536 0.74 HTR6 (0.39) HTR6GPR3HTR2AACHECHRM2
SCHEMBL30143298 0.73 HTR6 (0.37) HTR6ACHEBCHE
SCHEMBL7781754 0.72 MEN1 (0.33) GPR3
SCHEMBL7774595 0.72 GPR3 (0.31) GPR3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0991677-B1 PROCESS FOR THE PREPARATION OF COPOLYMERS OF ETHYLENE WITH ALPHA-OLEFINS BASELL POLYOLEFINE GMBH (DE) 2004-06-16 EP disclosed
US-20020156209-A1 Polymerization in the presence of metallocene catalysts with bridged bis-indenyl compounds BASELL TECHNOLOGY COMANY BV (NL) 2002-10-24 US disclosed
US-6448350-B1 Process for the preparation of copolymers of ethylene with alpha-olefins BASELL TECHNOLOGY COMPANY BV (NL) 2002-09-10 US disclosed
EP-0920403-B1 PROCESS FOR PREPARING CYCLOPENTADIENYL COMPOUNDS BASELL TECHNOLOGY CO BV (NL) 2002-01-30 EP disclosed
US-6268518-B1 AS POLYMERIZATION CATALYSTS FOR POLYMERIZATION OF OLEFINS MONTELL TECHNOLOGY COMPANY B.V. (NL) 2001-07-31 US disclosed
US-6162937-A Process for preparing cyclopentadienyl compounds MONTELL TECHNOLOGY COMPANY B.V. (NL) 2000-12-19 US disclosed
EP-0991677-A1 PROCESS FOR THE PREPARATION OF COPOLYMERS OF ETHYLENE WITH ALPHA-OLEFINS Montell Technology Company bv (NL) 2000-04-12 EP disclosed
WO-1999054369-A1 PROCESS FOR THE PREPARATION OF COPOLYMERS OF ETHYLENE WITH ALPHA-OLEFINS MONTELL TECHNOLOGY COMPANY B.V. (NL) 1999-10-28 WO disclosed
EP-0914323-A1 METALLOCENES AND CATALYSTS FOR POLYMERIZATION OF OLEFINS Montell Technology Company B.V. (NL) 1999-05-12 EP disclosed
WO-1998043989-A1 METALLOCENES AND CATALYSTS FOR POLYMERIZATION OF OLEFINS MONTELL TECHNOLOGY COMPANY B.V. (NL) 1998-10-08 WO disclosed