SCHEMBL7542646

SCHEMBL7542646

CC1=CC([Si](C)(C)C)c2ccccc21

nearest known ligand 0.34

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
GPR3 P46089 1/20 0.34
NPC1 O15118 2/20 0.32
RAB9A P51151 2/20 0.32
SMN1; SMN2 Q16637 2/20 0.32
CASP3 P42574 1/20 0.32
SENP8 Q96LD8 1/20 0.32
SENP7 Q9BQF6 1/20 0.32
SENP6 Q9GZR1 1/20 0.32
ALOX15 P16050 1/20 0.31
TDP1 Q9NUW8 1/20 0.31
MEN1 O00255 1/20 0.31
KMT2A Q03164 1/20 0.31
ATM Q13315 1/20 0.31
GAA P10253 1/20 0.30
TP53 P04637 1/20 0.30
PKM P14618 1/20 0.30
STAT3 P40763 1/20 0.30
STAT1 P42224 1/20 0.30
HTR2A P28223 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7936607 0.88 GPR3 (0.34) GPR3NPC1RAB9ASMN1; SMN2CASP3
SCHEMBL21029022 0.84 MEN1 (0.33) GPR3NPC1RAB9ASMN1; SMN2CASP3
SCHEMBL20996628 0.84 GPR3 (0.32) GPR3NPC1RAB9ASMN1; SMN2CASP3
SCHEMBL30307362 0.84 GPR3 (0.32) GPR3NPC1RAB9ASMN1; SMN2CASP3
SCHEMBL7944622 0.81 GPR3 (0.34) GPR3HTR2A
SCHEMBL7928077 0.78
SCHEMBL7542082 0.78 GPR3 (0.33) GPR3ALOX15TDP1
SCHEMBL29979921 0.78 GPR3 (0.33) GPR3ALOX15TDP1
SCHEMBL20920183 0.77 HTR6 (0.33) NPC1RAB9ASMN1; SMN2TDP1MEN1
SCHEMBL7632634 0.77

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0798306-B1 Substituted indenyl unbridged metallocenes PHILLIPS PETROLEUM CO (US) 2002-05-22 EP disclosed
CN-1065868-C substituted indenyl unbridged metallocenes PHILLIPS PETROLEUM CO (US) 2001-05-16 CN disclosed
CN-1272852-A Process for preparing ethylene and alpha-olefin copolymer MONTELL TECHNOLOGY COMPANY BV (NL) 2000-11-08 CN disclosed
US-6037427-A UNBRIDGED METALLOCENE CATALYSTS USED IN COMBINATION WITH SUITABLE COCATALYST FOR THE POLYMERIZATION OF OLEFINIC MONOMERS SCHMID CLAUDIA (DE) 2000-03-14 US disclosed
CN-1226894-A Metallocene and olefin polymerization catalyst MONTELL TECHNOLOGY COMPANY BV (NL) 1999-08-25 CN disclosed
CN-1226882-A Process for preparing cyclopentadienyl compounds MONTELL TECHNOLOGY COMPANY BV (NL) 1999-08-25 CN disclosed
US-5780659-A ADDITION POLYMERIZATION CATALYSTS PHILLIPS PETROLEUM COMPANY (US) 1998-07-14 US disclosed
CN-1164535-A Substituted indenyl unbridged metallocenes PHILLIPS PETROLEUM CO (US) 1997-11-12 CN disclosed
EP-0798306-A1 Substituted indenyl unbridged metallocenes PHILLIPS PETROLEUM COMPANY (US) 1997-10-01 EP disclosed