SCHEMBL8468840

SCHEMBL8468840

C[Si](C)(C1C=C(Cc2ccccc2)c2ccccc21)C1c2ccccc2-c2ccccc21

nearest known ligand 0.39

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
HTR6 P50406 3/20 0.39
PTPN1 P18031 1/20 0.33
NPC1 O15118 2/20 0.33
RAB9A P51151 2/20 0.33
SMN1; SMN2 Q16637 2/20 0.33
HPGD P15428 1/20 0.33
MAPK1 P28482 1/20 0.32
TDP1 Q9NUW8 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
CALM1 P0DP23 1/20 0.31
MAPT P10636 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7544944 0.83 ACHE (0.33) HTR6
SCHEMBL8466889 0.79 TOP2A (0.32)
Hydrochloric Acid SCHEMBL8680298 0.77 TOP2A (0.30)
SCHEMBL7944622 0.74 GPR3 (0.34)
SCHEMBL6910596 0.74 HTR6 (0.36) HTR6
SCHEMBL5175634 0.71 GPR3 (0.46)
SCHEMBL30143298 0.70 HTR6 (0.37) HTR6HPGD
SCHEMBL27945125 0.69 HTR6 (0.42) HTR6PTPN1MAPK1CALM1MAPT
Hydrochloric Acid SCHEMBL910454 0.68 HTR6 (0.41) HTR6PTPN1MAPK1CALM1MAPT
SCHEMBL28843652 0.68 HTR6 (0.68) HTR6PTPN1CALM1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5886202-A HAVING UNUSUAL EFFECTIVENESS AS CATALYSTS FOR THE POLYMERIZATION OF OLEFINS WHEN CERTAIN SUBSTITUENTS ARE AT THE 3 POSITION OF THE INDENE; HIGHER-MOLECULAR-WEIGHT POLYOLEFINS CHEVRON PHILLIPS CHEMICAL COMPANY LP 1999-03-23 US disclosed