Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 2/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.40 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.40 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | KIF11 | P52732 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA5A | P35218 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10497165 | 0.78 | AR (0.43) | ALDH1A1HTR7APPARSCN2A | |
| SCHEMBL6683239 | 0.78 | HTR7 (0.42) | ALDH1A1HTR7APPARSCN2A | |
| SCHEMBL15663248 | 0.77 | KIF11 (0.45) | ALDH1A1KIF11POLBCYP1A2CYP2C19 | |
| SCHEMBL2431522 | 0.77 | ENPP1 (0.39) | HTR7POLBPTGS1 | |
| SCHEMBL15639404 | 0.77 | ALDH1A1 (0.46) | ALDH1A1ADRA2AADRA2BADRA2CMAPK1 | |
| SCHEMBL455371 | 0.77 | ALDH1A1 (0.40) | ALDH1A1KIF11POLBMAPK1LMNA | |
| SCHEMBL10860408 | 0.76 | ACHE (0.46) | ALDH1A1HTR7APPARSCN2A | |
| SCHEMBL4669683 | 0.76 | AKR1C3 (0.40) | AKR1C3AKR1C2ABCC8KCNJ11ALDH1A1 | |
| SCHEMBL3678971 | 0.76 | ENPP1 (0.40) | AKR1C3AKR1C2ALDH1A1ADRA2AADRA2B | |
| SCHEMBL10476025 | 0.76 | KLRK1 (0.36) | ALDH1A1HTR7POLBCYP1A2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1432711-A1 | 1,6-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | Bayer Corporation (US) | 2004-06-30 | — | — | EP | disclosed |
| WO-2003027113-A1 | 1,6-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |