Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.69 |
| ▸ | LMNA | P02545 | 3/20 | 0.69 |
| ▸ | HTT | P42858 | 2/20 | 0.69 |
| ▸ | GAA | P10253 | 2/20 | 0.69 |
| ▸ | MEN1 | O00255 | 1/20 | 0.69 |
| ▸ | MAPT | P10636 | 2/20 | 0.67 |
| ▸ | POLB | P06746 | 1/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.62 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | P4HB | P07237 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | CA12 | O43570 | 1/20 | 0.55 |
| ▸ | CA1 | P00915 | 1/20 | 0.55 |
| ▸ | CA2 | P00918 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethylene SCHEMBL9048687 | 0.96 | KMT2A (0.65) | ALDH1A1KMT2ALMNAHTTGAA | |
| SCHEMBL5049885 | 0.90 | KMT2A (0.57) | ALDH1A1KMT2ALMNAHTTGAA | |
| SCHEMBL5056819 | 0.90 | KMT2A (0.57) | ALDH1A1KMT2ALMNAHTTGAA | |
| SCHEMBL5054683 | 0.90 | KMT2A (0.57) | ALDH1A1KMT2ALMNAHTTGAA | |
| SCHEMBL28141709 | 0.87 | KMT2A (0.61) | ALDH1A1KMT2ALMNAHTTGAA | |
| SCHEMBL7704838 | 0.85 | ALDH1A1 (0.67) | ALDH1A1KMT2ALMNAHTTMAPT | |
| SCHEMBL9316766 | 0.83 | ALDH1A1 (0.67) | ALDH1A1KMT2ALMNAHTTGAA | |
| SCHEMBL7868868 | 0.83 | KMT2A (0.61) | ALDH1A1KMT2ALMNAHTTGAA | |
| SCHEMBL20577928 | 0.83 | KMT2A (0.62) | ALDH1A1KMT2ALMNAHTTGAA | |
| SCHEMBL3062774 | 0.83 | ALDH1A1 (0.68) | ALDH1A1KMT2ALMNAMAPTCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3613755-A1 | LYSINE-SPECIFIC CHEMOENZYMATIC PROTEIN MODIFICATIONS USING MICROBIAL TRANSGLUTAMINASE | Novartis AG (CH) | 2020-02-26 | — | — | EP | disclosed |
| US-20160237116-A1 | SITE-SPECIFIC CHEMOENZYMATIC PROTEIN MODIFICATIONS | NOVARTIS AG | 2016-08-18 | — | — | US | disclosed |
| US-9359400-B2 | Site-specific chemoenzymatic protein modifications | NOVARTIS AG (CH) | 2016-06-07 | — | — | US | disclosed |
| US-20160102053-A1 | HETEROCYCLIC INHIBITORS OF NECROPTOSIS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-04-14 | — | — | US | disclosed |
| US-9108955-B2 | Heterocyclic inhibitors of necroptosis | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2015-08-18 | — | — | US | disclosed |
| WO-2015006728-A2 | SITE-SPECIFIC CHEMOENZYMATIC PROTEIN MODIFICATIONS | USERA AIMEE (US) | 2015-01-15 | — | — | WO | disclosed |
| US-20140128437-A1 | HETEROCYCLIC INHIBITORS OF NECROPTOSIS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2014-05-08 | — | — | US | disclosed |
| US-8658689-B2 | Heterocyclic inhibitors of necroptosis | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2014-02-25 | — | — | US | disclosed |
| US-8399448-B2 | 6-amino-pyrimidine-4-carboxamide derivatives and related compounds which bind to the sphingosine 1-phosphate (S1P) receptor for the treatment of multiple sclerosis | MERCK SERONO SA (CH) | 2013-03-19 | — | — | US | disclosed |
| US-20120309795-A1 | HETEROCYCLIC INHIBITORS OF NECROPTOSIS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2012-12-06 | — | — | US | disclosed |
| US-6727294-B2 | RADIATION TRANSPARENT MOLDING MATERIALS | MITSUBISHI ENGINEERING-PLASTICS CORPORATION (JP) | 2004-04-27 | — | — | US | disclosed |
| EP-0794218-B1 | Polycarbonate resin composition stabilized against radiation | MITSUBISHI ENG PLASTICS CORP (JP) | 2003-10-15 | — | — | EP | disclosed |
| EP-0753540-B1 | Polycarbonate resin composition | MITSUBISHI ENG PLASTICS CORP (JP) | 2003-06-11 | — | — | EP | disclosed |
| US-6359028-B1 | USED IN MEDICAL EQUIPMENT, DISCOLORATION INHIBITION | MITSUBISHI ENGINEERING-PLASTICS CORPORATION (JP) | 2002-03-19 | — | — | US | disclosed |
| US-20010034419-A1 | Radiation transparent molding materials | MITSUBISHI ENGINEERING-PLASTICS CORPORATION (JP) | 2001-10-25 | — | — | US | disclosed |
| US-6040367-A | EXCELLENT RESISTANCE TO AN IONIZING RADIATION, IN WHICH HETEROCYCLIC COMPOUND CONTAINING OXYMETHYLENE UNITS | MITSUBISHI ENGINEERING-PLASTICS CORPORATION (JP) | 2000-03-21 | — | — | US | disclosed |
| US-5977206-A | Polycarbonate resin composition | MITSUBISHI ENGINEERING-PLASTICS CORP. (JP) | 1999-11-02 | — | — | US | disclosed |
| US-5948838-A | 0.01 TO 5 PARTS BY WEIGHT OF A COMPOUND CONTAINING OXYMETHYLENE UNIT | MITSUBISHI ENGINEERING-PLASTICS CORP. (JP) | 1999-09-07 | — | — | US | disclosed |
| EP-0794218-A2 | Polycarbonate resin composition stabilized against radiation | MITSUBISHI ENGINEERING-PLASTICS CORPORATION (JP) | 1997-09-10 | — | — | EP | disclosed |
| EP-0753540-A2 | Polycarbonate resin composition | MITSUBISHI ENGINEERING-PLASTICS CORPORATION (JP) | 1997-01-15 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160102053-A1 | HETEROCYCLIC INHIBITORS OF NECROPTOSIS | TNF, RIPK1, RIPK3 | ALDH1A1 4587/4885KMT2A 3599/4885LMNA 2087/4885 |
| US-20160237116-A1 | SITE-SPECIFIC CHEMOENZYMATIC PROTEIN MODIFICATIONS | PTMS, TGM3, TGM1 | ALDH1A1 3164/4885KMT2A 198/4885LMNA 4444/4885 |
| US-20140128437-A1 | HETEROCYCLIC INHIBITORS OF NECROPTOSIS | TNF, RIPK1, RIPK3 | ALDH1A1 4587/4885KMT2A 3599/4885LMNA 2087/4885 |
| US-20120309795-A1 | HETEROCYCLIC INHIBITORS OF NECROPTOSIS | TNF, RIPK1, RIPK3 | ALDH1A1 4587/4885KMT2A 3599/4885LMNA 2087/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.