SCHEMBL6913488

SCHEMBL6913488

Cn1nc(-c2ccc(F)cc2F)cc1C(F)(F)F

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.42
RAB9A P51151 1/20 0.41
F2RL3 Q96RI0 1/20 0.39
PDK2 Q15119 1/20 0.39
GAA P10253 2/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
LMNA P02545 1/20 0.36
KMO O15229 2/20 0.36
PKM P14618 2/20 0.36
KDM4E B2RXH2 1/20 0.36
GLA P06280 1/20 0.36
ALPL P05186 1/20 0.36
PDE10A Q9Y233 1/20 0.36
PSEN1 P49768 1/20 0.35
PSEN2 P49810 1/20 0.35
APH1B Q8WW43 1/20 0.35
NCSTN Q92542 1/20 0.35
APH1A Q96BI3 1/20 0.35
PSENEN Q9NZ42 1/20 0.35
GRM5 P41594 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6906118 0.88 ALDH1A1 (0.42) ALDH1A1RAB9AGAAL3MBTL1LMNA
SCHEMBL3800985 0.88 F2RL3 (0.39) F2RL3PDK2KMOALPLPDE10A
SCHEMBL15814002 0.79 F2RL3 (0.42) ALDH1A1RAB9AF2RL3PDK2LMNA
SCHEMBL9529172 0.75 F2RL3 (0.39) F2RL3PDK2KMOPKMKDM4E
SCHEMBL7521846 0.75 ALDH1A1 (0.37) ALDH1A1RAB9AGAAL3MBTL1PKM
SCHEMBL19319837 0.74 ALDH1A1 (0.44) ALDH1A1RAB9APDK2GAAL3MBTL1
SCHEMBL8444970 0.74 TRPV4 (0.39) ALDH1A1RAB9AGAAL3MBTL1PKM
SCHEMBL27519042 0.74 ALDH1A1 (0.39) ALDH1A1RAB9AGAAL3MBTL1PKM
SCHEMBL16964034 0.73 ALDH1A1 (0.43) ALDH1A1RAB9AGAAL3MBTL1PKM
SCHEMBL19319848 0.73 RAB9A (0.40) ALDH1A1RAB9AGAAL3MBTL1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0791571-B1 Benzoyl derivatives BAYER CROPSCIENCE AG (DE) 2004-06-16 EP disclosed
EP-0553307-B1 HERBICIDAL SUBSTITUTED ARYL-HALOALKYLPYRAZOLES MONSANTO CO (US) 1998-12-09 EP disclosed
EP-0791571-A1 Benzoyl derivatives MONSANTO COMPANY (US) 1997-08-27 EP disclosed
US-5536700-A Herbicidal compositions comprising aryl-5-haloalkylpyrazoles and glyphosate, it's salts, diquat or paraquat MONSANTO COMPANY (US) 1996-07-16 US disclosed
US-5530126-A ALKYLATION IN INERT SOLVENT MONSANTO COMPANY (US) 1996-06-25 US disclosed
US-5496956-A BY ESTERIFICATION OF CARBOXY SUBSTITUTION WITH ALCOHOLS IN THE PRESENCE OF MINERAL ACID MONSANTO COMPANY (US) 1996-03-05 US disclosed
US-5489571-A CROP-SAFE COMPOUNDS EFFECTIVE AT LOW CONCENTRATIONS MONSANTO COMPANY (US) 1996-02-06 US disclosed
CN-1030595-C Substituted aryl-haloalkyl-pyrazoles as herbicides MONSANTO CO (US) 1996-01-03 CN disclosed
US-5281571-A Herbicidal benzoxazinone- and benzothiazinone-substituted pyrazoles MONSANTO COMPANY (US) 1994-01-25 US disclosed
EP-0553307-A1 HERBICIDAL SUBSTITUTED ARYL-HALOALKYLPYRAZOLES MONSANTO COMPANY (US) 1993-08-04 EP disclosed
WO-1992006962-A1 HERBICIDAL SUBSTITUTED ARYL-HALOALKYLPYRAZOLES MONSANTO COMPANY (US) 1992-04-30 WO disclosed