Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 8/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | SPR | P35270 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | AHR | P35869 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1458251 | 0.84 | PDE10A (0.44) | PDE10ALMNASPRSMN1; SMN2 | |
| SCHEMBL16220978 | 0.80 | ALDH1A1 (0.40) | MAPTALDH1A1PDE10ALMNAKDM4E | |
| SCHEMBL9926264 | 0.79 | PDE10A (0.39) | MAPTALDH1A1PDE10ALMNASPR | |
| SCHEMBL16212146 | 0.79 | ALDH1A1 (0.40) | MAPTALDH1A1PDE10ALMNAKDM4E | |
| SCHEMBL16212147 | 0.77 | ALDH1A1 (0.39) | MAPTALDH1A1LMNAKDM4EHTT | |
| SCHEMBL13772267 | 0.77 | SPR (0.38) | MAPTALDH1A1PDE10ALMNASPR | |
| SCHEMBL7511119 | 0.75 | LMNA (0.38) | MAPTALDH1A1PDE10ALMNAHTT | |
| SCHEMBL16260492 | 0.75 | SMN1; SMN2 (0.39) | ALDH1A1PDE10ALMNASPRSMN1; SMN2 | |
| SCHEMBL1458362 | 0.73 | RIPK2 (0.41) | MAPTALDH1A1LMNAKDM4EHTT | |
| SCHEMBL13772265 | 0.72 | HSD11B1 (0.42) | MAPTALDH1A1PDE10ALMNASPR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2991984-B1 | PALLADIUM-CATALYZED COUPLING OF PYRAZOLE AMIDES | HOFFMANN LA ROCHE (CH) | 2017-03-08 | — | — | EP | disclosed |
| EP-2991984-B1 | PALLADIUM-CATALYZED COUPLING OF PYRAZOLE AMIDES | HOFFMANN LA ROCHE (CH) | 2017-03-08 | — | — | EP | disclosed |
| US-9505759-B2 | Pd-catalyzed coupling of pyrazole amides | HOFFMANN-LA ROCHE INC. (US) | 2016-11-29 | — | — | US | disclosed |
| US-9505759-B2 | Pd-catalyzed coupling of pyrazole amides | HOFFMANN-LA ROCHE INC. (US) | 2016-11-29 | — | — | US | disclosed |
| US-9505759-B2 | Pd-catalyzed coupling of pyrazole amides | HOFFMANN-LA ROCHE INC. (US) | 2016-11-29 | — | — | US | disclosed |
| EP-2991984-A1 | Pd-CATALYZED COUPLING OF PYRAZOLE AMIDES | F. Hoffmann-La Roche AG (CH) | 2016-03-09 | — | — | EP | disclosed |
| US-20160046628-A1 | Pd-CATALYZED COUPLING OF PYRAZOLE AMIDES | HOFFMANN-LA ROCHE INC. (US) | 2016-02-18 | — | — | US | disclosed |
| US-20160046628-A1 | Pd-CATALYZED COUPLING OF PYRAZOLE AMIDES | HOFFMANN-LA ROCHE INC. (US) | 2016-02-18 | — | — | US | disclosed |
| US-20160046628-A1 | Pd-CATALYZED COUPLING OF PYRAZOLE AMIDES | HOFFMANN-LA ROCHE INC. (US) | 2016-02-18 | — | — | US | disclosed |
| WO-2014177493-A1 | Pd-CATALYZED COUPLING OF PYRAZOLE AMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 2014-11-06 | — | — | WO | disclosed |
| WO-2014177493-A1 | Pd-CATALYZED COUPLING OF PYRAZOLE AMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 2014-11-06 | — | — | WO | disclosed |
| WO-2011117264-A1 | N-(IMIDAZOPYRIMIDIN-7-YL)-HETEROARYLAMIDE DERIVATIVES AND THEIR USE AS PDE10A INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-09-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160046628-A1 | Pd-CATALYZED COUPLING OF PYRAZOLE AMIDES | PDE5A, PDE10A, PDE4B | MAPT 3919/4885ALDH1A1 866/4885PDE10A 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.