Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.44 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6919673 | 0.76 | KMT2A (0.41) | ALDH1A1KMT2AGAAMAPTKDM4E | |
| SCHEMBL2214214 | 0.72 | ALDH1A1 (0.43) | TDP1ALDH1A1GAAMAPT | |
| SCHEMBL6921028 | 0.71 | P2RX7 (0.38) | ALDH1A1MAPTKDM4E | |
| SCHEMBL25884516 | 0.70 | ALDH1A1 (0.69) | TDP1ALDH1A1MAPK8KMT2AGAA | |
| SCHEMBL13692388 | 0.69 | TDP1 (0.72) | TDP1ALDH1A1MAPK8KMT2AGAA | |
| SCHEMBL20831533 | 0.68 | TDP1 (0.72) | TDP1ALDH1A1MAPK8GAA | |
| SCHEMBL861902 | 0.68 | TDP1 (0.71) | TDP1ALDH1A1MAPK8KMT2AGAA | |
| SCHEMBL6920152 | 0.67 | SMN1; SMN2 (0.39) | TDP1ALDH1A1KMT2AGAAMAPT | |
| SCHEMBL20818012 | 0.66 | TDP1 (1.00) | TDP1ALDH1A1MAPK8KMT2AGAA | |
| SCHEMBL6919835 | 0.66 | L3MBTL1 (0.47) | ALDH1A1KMT2AGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004033431-A2 | HYDROXYPYRAZOLES FOR USE AGAINST METABOLIC-RELATED DISORDERS | ARENA PHARMACEUTICALS, INC. (US) | 2004-04-22 | — | — | WO | disclosed |