Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.39 |
| ▸ | NPC1 | O15118 | 4/20 | 0.38 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.37 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | MC4R | P32245 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | MC3R | P41968 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6919673 | 0.82 | KMT2A (0.41) | SMN1; SMN2HTTKDM4ENPC1RAB9A | |
| SCHEMBL2214214 | 0.80 | ALDH1A1 (0.43) | HTTALDH1A1HCAR2TSHRMAPT | |
| SCHEMBL6820940 | 0.79 | SMN1; SMN2 (0.35) | SMN1; SMN2HTTKDM4ENPC1RAB9A | |
| SCHEMBL6920029 | 0.76 | HCAR2 (0.39) | SMN1; SMN2HTTKDM4ENPC1RAB9A | |
| SCHEMBL6921028 | 0.76 | P2RX7 (0.38) | SMN1; SMN2HTTKDM4ENPC1RAB9A | |
| SCHEMBL6919835 | 0.73 | L3MBTL1 (0.47) | SMN1; SMN2HTTNPC1RAB9AALDH1A1 | |
| SCHEMBL6916937 | 0.73 | HCAR2 (0.41) | SMN1; SMN2HTTKDM4ENPC1RAB9A | |
| SCHEMBL10753599 | 0.69 | RAB9A (0.44) | SMN1; SMN2HTTKDM4ENPC1RAB9A | |
| SCHEMBL6918282 | 0.68 | ALDH1A1 (0.42) | SMN1; SMN2HTTNPC1RAB9AALDH1A1 | |
| SCHEMBL3186159 | 0.66 | KDM4E (0.70) | SMN1; SMN2KDM4ENPC1RAB9ANAPRT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004033431-A2 | HYDROXYPYRAZOLES FOR USE AGAINST METABOLIC-RELATED DISORDERS | ARENA PHARMACEUTICALS, INC. (US) | 2004-04-22 | — | — | WO | disclosed |