Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 4/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.39 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6922174 | 0.87 | MAPT (0.43) | LMNAKMT2APLOD2HTTSMN1; SMN2 | |
| SCHEMBL6920087 | 0.86 | LMNA (0.47) | LMNAKMT2ATDP1PLOD2HTT | |
| SCHEMBL6919541 | 0.84 | HTT (0.41) | LMNATDP1HTTKDM4EALDH1A1 | |
| SCHEMBL6919643 | 0.83 | L3MBTL1 (0.46) | LMNAKMT2AHTTSMN1; SMN2MEN1 | |
| SCHEMBL6919131 | 0.82 | ALDH1A1 (0.40) | KMT2AHTTSMN1; SMN2MEN1NPC1 | |
| SCHEMBL6922367 | 0.82 | HTT (0.40) | LMNATDP1PLOD2HTTRAB9A | |
| SCHEMBL6921074 | 0.81 | TBXAS1 (0.48) | LMNAKMT2APLOD2HTTSMN1; SMN2 | |
| SCHEMBL6921278 | 0.80 | TSHR (0.46) | PLOD2HTTSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL6920919 | 0.77 | TBXAS1 (0.52) | KMT2AHTTNPC1RAB9AKDM4E | |
| SCHEMBL6922335 | 0.77 | MAPT (0.41) | HTTSMN1; SMN2NPC1RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004033431-A2 | HYDROXYPYRAZOLES FOR USE AGAINST METABOLIC-RELATED DISORDERS | ARENA PHARMACEUTICALS, INC. (US) | 2004-04-22 | — | — | WO | claimed |
| WO-2004033431-A2 | HYDROXYPYRAZOLES FOR USE AGAINST METABOLIC-RELATED DISORDERS | ARENA PHARMACEUTICALS, INC. (US) | 2004-04-22 | — | — | WO | disclosed |