Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.39 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6921278 | 0.83 | TSHR (0.46) | MAPTHTTHPGDALOX15HSD17B10 | |
| SCHEMBL6920743 | 0.83 | NPC1 (0.42) | NPC1TP53RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL6919131 | 0.83 | ALDH1A1 (0.40) | MAPTHTTHPGDALOX15HSD17B10 | |
| SCHEMBL6922174 | 0.82 | MAPT (0.43) | MAPTHTTHPGDALOX15HSD17B10 | |
| SCHEMBL6920919 | 0.80 | TBXAS1 (0.52) | MAPTHTTHPGDALOX15HSD17B10 | |
| SCHEMBL6919541 | 0.80 | HTT (0.41) | MAPTHTTHPGDALOX15HSD17B10 | |
| SCHEMBL6921074 | 0.79 | TBXAS1 (0.48) | MAPTHTTHPGDALOX15HSD17B10 | |
| SCHEMBL6919643 | 0.79 | L3MBTL1 (0.46) | MAPTHTTHPGDALOX15HSD17B10 | |
| SCHEMBL6920008 | 0.78 | L3MBTL1 (0.41) | MAPTHTTHPGDALOX15HSD17B10 | |
| SCHEMBL6922367 | 0.78 | HTT (0.40) | MAPTHTTHPGDALOX15HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004033431-A2 | HYDROXYPYRAZOLES FOR USE AGAINST METABOLIC-RELATED DISORDERS | ARENA PHARMACEUTICALS, INC. (US) | 2004-04-22 | — | — | WO | claimed |
| WO-2004033431-A2 | HYDROXYPYRAZOLES FOR USE AGAINST METABOLIC-RELATED DISORDERS | ARENA PHARMACEUTICALS, INC. (US) | 2004-04-22 | — | — | WO | disclosed |