Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | APP | P05067 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.37 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6922174 | 0.88 | MAPT (0.43) | HTTMAPTHPGDALOX15HSD17B10 | |
| SCHEMBL6919541 | 0.85 | HTT (0.41) | HTTMAPTHPGDALOX15HSD17B10 | |
| SCHEMBL6921905 | 0.85 | LMNA (0.41) | HTTMAPTLMNACYP1A2CYP3A4 | |
| SCHEMBL6919643 | 0.84 | L3MBTL1 (0.46) | HTTMAPTHPGDALOX15HSD17B10 | |
| SCHEMBL6919131 | 0.83 | ALDH1A1 (0.40) | HTTMAPTHPGDALOX15HSD17B10 | |
| SCHEMBL6918790 | 0.82 | LMNA (0.42) | HTTMAPTHPGDALOX15HSD17B10 | |
| SCHEMBL6921278 | 0.81 | TSHR (0.46) | HTTMAPTHPGDALOX15HSD17B10 | |
| SCHEMBL6920919 | 0.78 | TBXAS1 (0.52) | HTTMAPTHPGDALOX15HSD17B10 | |
| SCHEMBL6922335 | 0.78 | MAPT (0.41) | HTTMAPTHPGDALOX15HSD17B10 | |
| SCHEMBL6921074 | 0.77 | TBXAS1 (0.48) | HTTMAPTHPGDALOX15HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004033431-A2 | HYDROXYPYRAZOLES FOR USE AGAINST METABOLIC-RELATED DISORDERS | ARENA PHARMACEUTICALS, INC. (US) | 2004-04-22 | — | — | WO | claimed |
| WO-2004033431-A2 | HYDROXYPYRAZOLES FOR USE AGAINST METABOLIC-RELATED DISORDERS | ARENA PHARMACEUTICALS, INC. (US) | 2004-04-22 | — | — | WO | disclosed |