Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 known ✓ | P25103 | 8/20 | 0.33 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.31 |
| ▸ | KIF11 | P52732 | 1/20 | 0.34 |
| ▸ | RXRA | P19793 | 4/20 | 0.33 |
| ▸ | RXRB | P28702 | 4/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | RXRG | P48443 | 3/20 | 0.32 |
| ▸ | ATP1A1 | P05023 | 1/20 | 0.32 |
| ▸ | ATP1B1 | P05026 | 1/20 | 0.32 |
| ▸ | ATP1A3 | P13637 | 1/20 | 0.32 |
| ▸ | ATP1B2 | P14415 | 1/20 | 0.32 |
| ▸ | ATP1A2 | P50993 | 1/20 | 0.32 |
| ▸ | ATP1B3 | P54709 | 1/20 | 0.32 |
| ▸ | FXYD2 | P54710 | 1/20 | 0.32 |
| ▸ | ATP1A4 | Q13733 | 1/20 | 0.32 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6290431 | 0.92 | IKBKB (0.33) | RXRARXRBRXRG | |
| Hydrochloric Acid SCHEMBL6926682 | 0.81 | KIF11 (0.34) | KIF11RXRARXRBTACR1CNR1 | |
| Hydrochloric Acid SCHEMBL6930183 | 0.79 | KIF11 (0.37) | KIF11SLC6A2 | |
| Hydrochloric Acid SCHEMBL6287543 | 0.72 | PTGS2 (0.33) | TDP1 | |
| Hydrochloric Acid SCHEMBL6289768 | 0.71 | RXRA (0.33) | RXRARXRBRXRG | |
| Hydrochloric Acid SCHEMBL8364572 | 0.68 | IKBKB (0.33) | RXRARXRBRXRG | |
| Hydrochloric Acid SCHEMBL8367747 | 0.66 | — | — | |
| Hydrochloric Acid SCHEMBL8367981 | 0.66 | TACR1 (0.30) | TACR1 | |
| SCHEMBL2138447 | 0.66 | KIF11 (0.65) | KIF11RXRARXRBTACR1CNR1 | |
| SCHEMBL4266470 | 0.66 | KIF11 (0.54) | KIF11RXRARXRBTACR1RXRG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6518378-B2 | Using an unbridged cyclopentadienyl metallocene catalyst capable of interconverting between states with different copolymerization characteristics | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 2003-02-11 | — | — | US | disclosed |
| US-6479685-B2 | POLYMERIZING ETHYLENE AND ANOTHER ALPHA-OLEFIN IN THE PRESENCE OF AN UNBRIDGED, ROTATING, NON-RIGID FLUXIONAL METALLOCENE CATALYST COMPONENT AND A CO-CATALYST | THE BOARD OF TRUSTEES OF THE LELAND STANDARD JUNIOR UNIVERSITY | 2002-11-12 | — | — | US | disclosed |
| US-20010049425-A1 | High-melting polyolefin copolymer elastomers, catalysts and methods of synthesis | BP CORPORATION NORTH AMERICA INC. | 2001-12-06 | — | — | US | disclosed |
| US-20010034426-A1 | High-melting polyolefin copolymer elastomers, catalysts and methods of synthesis | BP CORPORATION NORTH AMERICA INC. | 2001-10-25 | — | — | US | disclosed |
| US-6169151-B1 | MADE BY POLYMERIZING ETHYLENE AND ALPHA-OLEFIN(S) USING AN UNBRIDGED, ROTATING, NON-RIGID FLUXIONAL METALLOCENE CATALYST AND COCATALYST; CRYSTALLIZABLE ELASTOMERIC COPOLYMER PRODUCT HAS HIGHER MELTING POINT, NARROW COMPOSITION DISTRIBUTION | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 2001-01-02 | — | — | US | disclosed |