Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C2 | P08235 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.46 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.46 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.43 |
| ▸ | G6PC1 | P35575 | 1/20 | 0.41 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8620760 | 0.98 | NR3C2 (0.49) | NR3C2ALDH1A1CYP2A6HDAC1HDAC8 | |
| SCHEMBL6928851 | 0.94 | HDAC1 (0.51) | NR3C2ALDH1A1CYP2A6HDAC1HDAC8 | |
| SCHEMBL6927897 | 0.89 | HDAC1 (0.48) | NR3C2ALDH1A1CYP2A6HDAC1HDAC8 | |
| SCHEMBL9446230 | 0.84 | NR3C2 (0.59) | NR3C2ALDH1A1HDAC1HDAC8HDAC6 | |
| SCHEMBL1165356 | 0.83 | CYP2C19 (0.58) | ALDH1A1CYP2A6ALDH3A1ALDH1A3TSHR | |
| SCHEMBL918512 | 0.82 | NR3C2 (0.56) | NR3C2ALDH1A1HDAC1HDAC8HDAC6 | |
| SCHEMBL7147228 | 0.81 | ALDH1A1 (0.59) | NR3C2ALDH1A1CYP2A6ALDH3A1ALDH1A3 | |
| SCHEMBL4049989 | 0.80 | CYP2A6 (0.52) | ALDH1A1CYP2A6ALDH3A1ALDH1A3TSHR | |
| Bromide SCHEMBL4613403 | 0.80 | NR3C2 (0.55) | NR3C2ALDH1A1HDAC1HDAC8HDAC6 | |
| Biphenyl SCHEMBL9239362 | 0.79 | CYP2C19 (0.53) | ALDH1A1CYP2A6ALDH3A1ALDH1A3TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6518268-B1 | Telomerase inhibitors and methods of their use | GERON CORPORATION | 2003-02-11 | — | — | US | disclosed |
| CN-1321153-A | telomerase inhibitors and methods of use thereof | GERON CORP (US) | 2001-11-07 | — | — | CN | disclosed |
| WO-2001002377-A9 | TELOMERASE INHIBITORS AND METHODS OF THEIR USE | GERON CORP (US) | 2001-10-11 | — | — | WO | disclosed |
| EP-1109796-A1 | TELOMERASE INHIBITORS AND METHODS OF THEIR USE | Geron Corporation (US) | 2001-06-27 | — | — | EP | disclosed |
| WO-2001002377-A1 | TELOMERASE INHIBITORS AND METHODS OF THEIR USE | GERON CORPORATION (US) | 2001-01-11 | — | — | WO | disclosed |