Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3260707 | 0.86 | NR1H2 (0.46) | MAPTNPC1RAB9APOLBTP53 | |
| SCHEMBL6924866 | 0.85 | MAPT (0.38) | MAPKAPK2MAPTNPC1RAB9APOLB | |
| SCHEMBL28133306 | 0.81 | NPC1 (0.56) | MAPTNPC1RAB9ATP53ALDH1A1 | |
| SCHEMBL27135558 | 0.81 | MAPT (0.42) | MAPTNPC1RAB9APOLBTP53 | |
| SCHEMBL8188422 | 0.77 | PDE4B (0.46) | MAPTNPC1RAB9APOLBTP53 | |
| SCHEMBL7542738 | 0.75 | ALDH1A1 (0.39) | RAB9AALDH1A1SMN1; SMN2CYP1A2HPGD | |
| SCHEMBL18627698 | 0.75 | L3MBTL1 (0.56) | MAPTNPC1RAB9APOLBTP53 | |
| SCHEMBL4101559 | 0.74 | SREBF2 (0.48) | MAPTNPC1RAB9APOLBALDH1A1 | |
| SCHEMBL10162103 | 0.73 | ADRB2 (0.63) | MAPTNPC1RAB9APOLBTP53 | |
| SCHEMBL2914914 | 0.73 | TP53 (0.68) | MAPTNPC1RAB9ATP53ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6518424-B1 | Activity as inhibitors of phospholipase A2, and are useful in treating disorders mediated by phospholipase A2 and antiinflammatory agents | ELAN PHARMACEUTICALS, INC. | 2003-02-11 | — | — | US | disclosed |
| WO-2000027824-A1 | SUBSTITUTED PYRIMIDINE COMPOSITIONS AND METHODS OF USE | ELAN PHARMACEUTICALS (US) | 2000-05-18 | — | — | WO | disclosed |