SCHEMBL7542738

SCHEMBL7542738

Clc1nccc(Cc2ccc(-c3ccccc3)cc2)n1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.39
CYP11B1 P15538 3/20 0.38
CYP11B2 P19099 3/20 0.38
CYP17A1 P05093 1/20 0.38
TSHR P16473 1/20 0.38
TAAR1 Q96RJ0 1/20 0.37
MPO P05164 1/20 0.37
L3MBTL1 Q9Y468 3/20 0.37
GABRA1 P14867 1/20 0.36
GABRB2 P47870 1/20 0.36
CYP1A2 P05177 1/20 0.36
CNR2 P34972 2/20 0.36
CNR1 P21554 1/20 0.36
TRPV1 Q8NER1 1/20 0.36
CES1 P23141 1/20 0.36
SMN1; SMN2 Q16637 2/20 0.36
RAB9A P51151 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
MEN1 O00255 1/20 0.35
HPGD P15428 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL265376 0.90 ALDH1A1 (0.47) ALDH1A1TAAR1L3MBTL1CYP1A2SMN1; SMN2
SCHEMBL7674816 0.79 HTR2C (0.38) CYP11B1CYP11B2MPOCNR2CNR1
SCHEMBL17537258 0.78 NR4A2 (0.42) ALDH1A1TSHRMEN1HPGDKMT2A
SCHEMBL7672911 0.75 MBOAT4 (0.44) TAAR1TRPV1
SCHEMBL7675792 0.75 CYP19A1 (0.44) ALDH1A1CYP11B1CYP11B2CYP1A2HPGD
SCHEMBL6924869 0.75 MAPKAPK2 (0.42) ALDH1A1L3MBTL1CYP1A2SMN1; SMN2RAB9A
SCHEMBL3260707 0.74 NR1H2 (0.46) ALDH1A1TSHRL3MBTL1CYP1A2SMN1; SMN2
SCHEMBL17898217 0.74 KCNH2 (0.57) ALDH1A1CYP1A2SMN1; SMN2RAB9AMEN1
SCHEMBL3410050 0.73 PNMT (0.43) CYP11B1CYP11B2TAAR1MPO
SCHEMBL118923 0.73 L3MBTL1 (0.65) ALDH1A1TSHRTAAR1L3MBTL1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6319922-B1 ALPHA-PYRIMIDYL-SUBSTITUTED; USEFUL FOR TREATING DISEASES INCLUDING INFLAMMATORY DISEASES, AND DISEASES INVOLVING ANGIOGENESIS, BONE RESORPTION OR CELLULAR OR MATRIX OVER-EXPANSION. CELLTECH THERAPEUTICS LIMITED (GB) 2001-11-20 US disclosed
EP-1133488-A1 PROPANOIC ACID DERIVATIVES AS INTEGRIN INHIBITORS CELLTECH THERAPEUTICS LIMITED (GB) 2001-09-19 EP disclosed
WO-2000031067-A1 PROPANOIC ACID DERIVATIVES AS INTEGRIN INHIBITORS CELLTECH THERAPEUTICS LIMITED (GB) 2000-06-02 WO disclosed