Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 6/20 | 0.53 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.52 |
| ▸ | CNR2 | P34972 | 1/20 | 0.52 |
| ▸ | SRC | P12931 | 1/20 | 0.50 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.48 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.48 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.47 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | EDNRB | P24530 | 2/20 | 0.45 |
| ▸ | EDNRA | P25101 | 2/20 | 0.45 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6920467 | 0.90 | PLA2G2A (0.55) | PLA2G2AP2RX4PLA2G1B | |
| SCHEMBL6921173 | 0.81 | CYP19A1 (0.65) | PLA2G2ASRCP2RX4HDAC1HDAC6 | |
| SCHEMBL6921601 | 0.79 | PLA2G2A (0.47) | PLA2G2APLA2G10CNR2MTNR1AMTNR1B | |
| SCHEMBL6919685 | 0.78 | PLA2G2A (0.44) | PLA2G2APLA2G10CNR2MTNR1AMTNR1B | |
| SCHEMBL6923659 | 0.75 | KMT2A (0.51) | PLA2G2ASRCP2RX4TP53ALDH1A1 | |
| SCHEMBL7517440 | 0.75 | TSHR (0.56) | PLA2G2AP2RX4PLA2G1BNTRK1 | |
| SCHEMBL7723992 | 0.75 | SRC (0.53) | PLA2G2ASRCP2RX4ALDH1A1POLB | |
| SCHEMBL27901716 | 0.74 | KMT2A (0.55) | PLA2G2APLA2G10PLA2G1BTP53ALDH1A1 | |
| SCHEMBL6924327 | 0.74 | SRC (0.51) | PLA2G2ASRCP2RX4HDAC1HDAC6 | |
| SCHEMBL4169248 | 0.73 | HASPIN (0.61) | PLA2G2APLA2G10CNR2MTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6514968-B1 | Treating a disease or condition in a mammal wherein the 5-HT receptor is implicated and modulation of 5-HT function is desired comprising | PHARMACIA & UPJOHN COMPANY | 2003-02-04 | — | — | US | disclosed |
| EP-1210329-A2 | AMINOALKOXY CARBAZOLES AND THEIR USE AS 5-HT LIGANDS | PHARMACIA & UPJOHN COMPANY (US) | 2002-06-05 | — | — | EP | disclosed |
| WO-2001017963-A2 | AMINOALKOXY CARBAZOLES AND THEIR USE AS 5-HT LIGANDS | PHARMACIA & UPJOHN COMPANY (US) | 2001-03-15 | — | — | WO | disclosed |