Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 2/20 | 0.44 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.44 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.43 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.43 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.43 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.43 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.43 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 4/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.41 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.41 |
| ▸ | CLK1 | P49759 | 1/20 | 0.41 |
| ▸ | CLK2 | P49760 | 1/20 | 0.41 |
| ▸ | CLK3 | P49761 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6924426 | 0.92 | TSHR (0.47) | PLA2G2ANTRK1MAPTSMN1; SMN2P2RX4 | |
| SCHEMBL6921601 | 0.84 | PLA2G2A (0.47) | PLA2G2APLA2G10TP53NTRK1MAPT | |
| SCHEMBL6923666 | 0.81 | KMT2A (0.44) | PLA2G2APLA2G10MAPTSMN1; SMN2P2RX4 | |
| SCHEMBL6925937 | 0.78 | PLA2G2A (0.53) | PLA2G2APLA2G10TP53NTRK1CNR2 | |
| SCHEMBL818659 | 0.75 | PLA2G2A (0.43) | PLA2G2APLA2G10MAPTSMN1; SMN2 | |
| SCHEMBL6924402 | 0.75 | HTR6 (0.49) | PLA2G2ANTRK1ALDH1A1POLBHTT | |
| SCHEMBL6921062 | 0.75 | MAPT (0.39) | PLA2G2APLA2G10TP53MAPTP2RX4 | |
| SCHEMBL31511289 | 0.72 | PLA2G2A (0.41) | PLA2G2APLA2G10MAPTSMN1; SMN2 | |
| SCHEMBL28527831 | 0.72 | PLA2G2A (0.41) | PLA2G2APLA2G10MAPTSMN1; SMN2 | |
| SCHEMBL6921602 | 0.72 | ABCG2 (0.48) | PLA2G2ATP53NTRK1MAPTMTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6514968-B1 | Treating a disease or condition in a mammal wherein the 5-HT receptor is implicated and modulation of 5-HT function is desired comprising | PHARMACIA & UPJOHN COMPANY | 2003-02-04 | — | — | US | disclosed |
| EP-1210329-A2 | AMINOALKOXY CARBAZOLES AND THEIR USE AS 5-HT LIGANDS | PHARMACIA & UPJOHN COMPANY (US) | 2002-06-05 | — | — | EP | disclosed |
| WO-2001017963-A2 | AMINOALKOXY CARBAZOLES AND THEIR USE AS 5-HT LIGANDS | PHARMACIA & UPJOHN COMPANY (US) | 2001-03-15 | — | — | WO | disclosed |